S153
SQ 22536
≥97% (HPLC), Adenylate cyclase inhibitor, powder
别名:
9-THF-Ade, 9-（四氢-2-呋喃基）-9H-嘌呤-6-胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C9H11N5O
化学文摘社编号:
分子量:
205.22
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SQ 22,536, ≥97% (HPLC), powder
SMILES string
Nc1ncnc2n(cnc12)C3CCCO3
InChI
1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
InChI key
UKHMZCMKHPHFOT-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL, H2O: insoluble
Quality Level
Gene Information
human ... ADCY1(107), ADCY2(108), ADCY3(109), ADCY4(196883), ADCY5(111), ADCY6(112), ADCY7(113), ADCY8(114), ADCY9(115)
rat ... Adora1(29290), Adora2a(25369)
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Application
SQ 22,536已被用于研究腺苷酸环化酶在PC12细胞分化 和乳腺癌细胞中的间隙连接细胞间通讯中的作用。
Biochem/physiol Actions
SQ 22,536不仅是血小板中基础腺苷酸环化酶，也是前列腺素E1激活的腺苷酸环化酶活性的有效抑制剂。1 当对大鼠进行肌肉注射时，它可以对侧和同侧逆转痛觉过敏。2
SQ 22,536是一种细胞可渗透的腺苷酸环化酶抑制剂。在去污剂剂分散的大鼠脑制剂中，IC50 = 20 μM。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
R J Haslam et al.
The Biochemical journal, 176(1), 83-95 (1978-10-15)
Whereas adenosine itself exerted independent stimulatory and inhibitory effects on the adenylate cyclase activity of a platelet particulate fraction at low and high concentrations respectively, 2-substituted and N6-monosubstituted adenosines had stimulatory but greatly decreased inhibitory effects. Deoxyadenosines, on the other
Marie K Hoeger-Bement et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(13), 5437-5445 (2003-07-05)
Spinal activation of the cAMP pathway produces mechanical hyperalgesia, sensitizes nociceptive spinal neurons, and phosphorylates the transcription factor cAMP-responsive element binding protein (CREB), which initiates gene transcription. This study examined the role of the cAMP pathway in a model of
Soo Hyeon Kim et al.
Blood, 120(24), 4892-4902 (2012-10-18)
In cancer, VEGF-induced increase in vascular permeability results in increased interstitial pressure, reducing perfusion and increasing hypoxia, which reduce delivery of chemotherapeutic agents and increase resistance to ionizing radiation. Here, we show that both TIMP-2 and Ala + TIMP-2, a
Sören Brandenburg et al.
Journal of molecular and cellular cardiology, 165, 141-157 (2022-01-17)
Axial tubule junctions with the sarcoplasmic reticulum control the rapid intracellular Ca2+-induced Ca2+ release that initiates atrial contraction. In atrial myocytes we previously identified a constitutively increased ryanodine receptor (RyR2) phosphorylation at junctional Ca2+ release sites, whereas non-junctional RyR2 clusters
Sangwoo Shim et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(23), e2220037120-e2220037120 (2023-05-30)
The balance between neural stem cell proliferation and neuronal differentiation is paramount for the appropriate development of the nervous system. Sonic hedgehog (Shh) is known to sequentially promote cell proliferation and specification of neuronal phenotypes, but the signaling mechanisms responsible
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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