生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8 μg/mL using human pancreas, Islets of Langerhans
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... SSTR1(6751)
mouse ... Sstr1(20605)
rat ... Sstr1(25033)
一般描述
Somatostatin Receptor Type 1 (SSTR1) is present in blood vessels, neuroendocrine cells, and the retina. SSTR1 gene is mapped to human chromosome 14q21.1.
免疫原
synthetic peptide corresponding to the C-terminal of human somatostatin receptor type 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
生化/生理作用
Somatostatin Receptor Type 1 (SSTR1) protein extracellular loop regions are crucial for ligand binding. SSTR1 gene down-regulated in reported in preeclampsia but it is overexpressed in breast cancer. It is reported to block the mitogen-activated protein kinase (MAPK) pathway. However, in pancreatic cell lines, elevated expression of SSTR1 gene favors cell cycle arrest. SSTR1 also plays a tumor suppressor role in gastric cancer invasion.
外形
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J Zhao et al.
British journal of cancer, 108(12), 2557-2564 (2013-06-01)
Somatostatin receptor 1 (SSTR1) was preferentially methylated in Epstein-Barr virus (EBV)-positive gastric cancer using promoter methylation array. We aimed to analyse the epigenetic alteration and biological function of SSTR1 in EBV-associated gastric cancer (EBVaGC). Promoter methylation was examined by combined
Santhosh Kumar Nagarajan et al.
ACS omega, 5(33), 21145-21161 (2020-09-03)
Somatostatin receptor 1 (SSTR1), a subtype of somatostatin receptors, is involved in various signaling mechanisms in different parts of the human body. Like most of the G-protein-coupled receptors (GPCRs), the available information on the structural features of SSTR1 responsible for
Yi Zou et al.
Oncology letters, 17(2), 1723-1731 (2019-01-25)
Somatostatin receptors (SSTRs) are G-protein-coupled plasma membrane receptors that have been determined to be expressed in normal and cancer tissues. Activation of SSTRs frequently results in inhibition of cell proliferation and therefore somatostatin analogues (SSAs) have been used in cancer
Y-H Yan et al.
European review for medical and pharmacological sciences, 17(22), 3083-3094 (2013-12-05)
Preeclampsia is a complication of pregnancy that severely threatens the health of the mother and infant, yet the mechanism of pathogenesis remains unclear. In this article, gene array technology was applied to identify the genes related to the pathogenesis of
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