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Merck
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文件

安全信息

S0885

Sigma-Aldrich

生长抑素

γ-irradiated, powder, BioXtra, suitable for cell culture

别名:

SRIF, 促生长素释放抑制因子, 生长抑素-14, 生长激素释放抑制因子

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About This Item

经验公式（希尔记法）:
C76H104N18O19S2
CAS号:
38916-34-6
分子量:
1637.88
Beilstein:
6436064
EC 号:
254-186-5
MDL编号:
MFCD00076762
UNSPSC代码:
12352209
PubChem化学物质编号:
24899450
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

无菌性

γ-irradiated

产品线

BioXtra

形式

powder

效能

0.3-50 ng/mL

浓度

≥50% (HPLC)

技术

cell culture | mammalian: suitable

溶解性

cell culture medium: 10 mL/vial

运输

ambient

储存温度

−20°C

SMILES字符串

[H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O

InChI

1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57?,58-,59-,62-,63-/m0/s1

InChI key

NHXLMOGPVYXJNR-FQSIDJEASA-N

基因信息

human ... SSTR1(6751) , SSTR2(6752) , SSTR3(6753) , SSTR4(6754) , SSTR5(6755)

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Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

生化/生理作用

Somatostatin regulates endocrine function and cell proliferation via interaction with G-protein-coupled somatostatin receptors. It exists in two active forms produced by alternative cleavage of a single preproprotein (14 aa and 28 aa forms). Somatosatin inhibits the release of growth hormone; thyroid-stimulating hormone and a range of gastrointestinal hormones: Cholecystokinin (CCK); Enteroglucagon; Gastrin; Gastric inhibitory polypeptide (GIP); Motilin; Secretin; Vasoactive intestinal peptide (VIP).

外形

0°C 下为粉末状；分成小份冻存，以避免使用时重复冰冻/解冻

重悬

加入 10mL 无菌培养基可制成 2μg/mL 的储存液。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Henrik H Hansen et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 657-664 (2014-07-06)
Type 2 diabetes is characterized by impaired β-cell function associated with progressive reduction of insulin secretion and β-cell mass. Evidently, there is an unmet need for treatments with greater sustainability in β-cell protection and antidiabetic efficacy. Through an insulin and
Yuko Takano et al.
PloS one, 10(7), e0133812-e0133812 (2015-07-21)
Animal models with defective glucagon action show hyperplasia of islet α-cells, however, the regulatory mechanisms underlying the proliferation of islet endocrine cells remain largely to be elucidated. The Gcggfp/gfp mice, which are homozygous for glucagon/green fluorescent protein knock-in allele (GCGKO)
Amelie Soumier et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2252-2262 (2014-04-03)
Reduced expression of somatostatin (SST) is reported across chronic brain conditions including major depression and normal aging. SST is a signaling neuropeptide and marker of gamma-amino butyric acid (GABA) neurons, which specifically inhibit pyramidal neuron dendrites. Studies in auditory cortex
Zaki Alsahafi et al.
The Journal of physiology, 593(16), 3673-3692 (2015-05-27)
This study investigates the effects on ventilation of an excitatory stimulus delivered in a spatially and temporally precise manner to the inspiratory oscillator, the preBötzinger complex (preBötC). We used an adeno-associated virus expressing channelrhodopsin driven by the synapsin promoter to
M Hadi Saiepour et al.
Current biology : CB, 25(6), 713-721 (2015-03-11)
To ensure that neuronal networks function in a stable fashion, neurons receive balanced inhibitory and excitatory inputs. In various brain regions, this balance has been found to change temporarily during plasticity. Whether changes in inhibition have an instructive or permissive
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