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SB-366791

Name: SB-366791
Brand: SIGMA

≥98% (HPLC), powder

别名:

N-(3-Methoxyphenyl)-4-chlorocinnamide

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₄NO₂Cl

化学文摘社编号:

472981-92-3

分子量:

287.74

NACRES:

NA.77

PubChem Substance ID:

24278690

UNSPSC Code:

12352200

MDL number:

MFCD01033818

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

originator

GlaxoSmithKline

SMILES string

COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1

InChI

1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+

InChI key

RYAMDQKWNKKFHD-JXMROGBWSA-N

Gene Information

human ... TRPV1(7442)

说明

Application

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:

to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)

Biochem/physiol Actions

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.

Vanilloid receptor-1 (TRPV1) antagonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain.

Y Niiyama et al.

British journal of anaesthesia, 102(2), 251-258 (2008-11-29)

Bone cancer pain has a major impact on the quality of life of cancer patients but is difficult to treat. Therefore, development of a novel strategy for bone cancer pain is needed for improvement of the patient quality of life.

Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle.

Riccardo Patacchini et al.

European journal of pharmacology, 509(2-3), 171-177 (2005-03-01)

We have investigated the mechanism through which hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat isolated urinary bladder. Sodium hydrogen sulfide (NaHS), a donor of H2S, produced concentration-dependent contractile responses (pEC50=3.5+/-0.1) that were unaffected by the transient

SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain

Niiyama Y, et al.

British Journal of Anaesthesia, 102(2), 251-258 (2009)

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