推荐产品
生物来源
Streptococcus pyogenes
质量水平
无菌性
γ-irradiated
表单
lyophilized powder
应用
cell analysis
储存温度
2-8°C
基因信息
Streptococcus pyogenes ... slo(900490)
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应用
Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.
透膜允许细胞摄取大分子或带电分子。
生化/生理作用
能穿透动物细胞膜的巯基活化毒素。该蛋白作为单体与膜胆固醇结合，随后聚合成围绕>12 nm孔的大弧形和环形结构。
Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.
单位定义
One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.
制备说明
Prepared from S 5265
警示用语：
Danger
危险分类
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Extended exposure duration of cultured intestinal epithelial cell monolayers in characterizing hazardous and non-hazardous proteins
Zimmermann C, et al.
Food And Chemical Toxicology, 115(4), 451-459 (2018)
Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers
Vassilev B, et al.
The American Journal of Pathology, 185(4), 987-1000 (2015)
Streptolysin O derived from Streptococcus pyogenes inhibits RANKL-induced osteoclastogenesis through the NF-kappaB signaling pathway
Yi J, et al.
Molecular Medicine Reports (2018)
Quan D Zhou et al.
Nature immunology, 21(7), 746-755 (2020-06-10)
Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane cholesterol for their effector function. Phagocytes are essential for clearance of CDC-producing bacteria; however, the mechanisms by which these
Mingqun Lin et al.
Autophagy, 12(11), 2145-2166 (2016-11-02)
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes a potentially fatal emerging zoonosis, human monocytic ehrlichiosis. E. chaffeensis has a limited capacity for biosynthesis and metabolism and thus depends mostly on host-synthesized nutrients for growth. Although the host cell
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