species reactivity
human
technique(s)
ELISA: suitable
assay range
inter-assay cv: <10%
intra-assay cv: <12%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... JAK2(3717)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Janus kinase 2 (JAK2) mediates epithelial-mesenchymal transition in hepatocellular carcinoma. The JAK2/STAT3 signaling pathway is associated with tumor development in a number of cancer such as gastric cancer. Mutation in the JAK2 gene is known to activate JAK2 receptor action even in the absence of ligand, inducing cell proliferation and opposing apoptosis.
General description
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-JAK2. The JAK2 (Janus kinase 2) gene is mapped to human chromosome 9p24.1.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
Zhou J, et al.
Oncology Reports, 38(2), 1059-1066 (2017)
CD 274 (PDL 1) and JAK 2 genomic amplifications in pulmonary squamous?cell and adenocarcinoma patients.
Clave S, et al.
Histopathology, 72(2), 259-269 (2018)
Norcantharidin inhibits IL-6-induced epithelial?mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.
Gao Y, et al.
Oncology Reports, 38(2), 1224-1232 (2017)
The genetic basis of haematological cancers (2016)
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