species reactivity
porcine
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 4 μIU/mL
standard curve range: 4.69 μIU/ml-300 μIU/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
Porcine ... INS(397415)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Abnormal insulin secretion or function, leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. Insulin is known to stimulate cell division. The biological effects of insulin are mediated by insulin receptor and it integrates major signaling pathways.
General description
The antibody reacts specifically against insulin by RIA and immunocytochemistry. It exhibits cross-reactivity with human proinsulin. The antibody binds to insulin with an affinity constant of 8.8 × 109 M-1 in RIA. The insulin gene is mapped to human chromosome 11p15.5.
Human insulin is made up of 51 amino acids. It consists of two peptide chains, 21 amino acids make up A-chain and chain B contains 31 amino acids. The two chains are linked together by a disulfide bond, to form a classical insulin fold with three α helices, chain A having two and one in chain B.
Human insulin is made up of 51 amino acids. It consists of two peptide chains, 21 amino acids make up A-chain and chain B contains 31 amino acids. The two chains are linked together by a disulfide bond, to form a classical insulin fold with three α helices, chain A having two and one in chain B.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Kinetic properties of monoclonal insulin antibodies.
Keilacker H, et al.
Biomedica Biochimica Acta, 45(8), 1093-1102 (1986)
Proinsulin-Specific Monoclonal Antibodies: Immunocytochemical Application as ?-Cell Markers and as Probes for Conversion.
Madsen O D
Diabetes, 36(10), 1203-1211 (1987)
Genetic linkage of Beckwith-Wiedemann syndrome to 11p15.
Ping A J, et al.
American Journal of Human Genetics, 44(5), 720-720 (1989)
The molecular mechanism of insulin action.
Kahn C R
Annual Review of Medicine, 36(1), 429-451 (1985)
S Witt et al.
Acta histochemica. Supplementband, 35, 217-223 (1988-01-01)
Murine monoclonal antibodies against glucagon and insulin were generated by somatic cell hybridization and partially characterized. The monoclonal glucagon antibody K79bB10 exhibited no cross-reaction with gut glucagon. This antibody and the insulin antibody K36aC10 were found of very high concentration
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