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种属反应性
mouse
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
capture ELISA: suitable
输入
sample type plasma
sample type serum
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 30 pg/mL
standard curve range: 27.43-20000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Prl(19109)
一般描述
The Mouse Prolactin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse Prolactin in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Mouse Prolactin
应用
请参考Protocol了解详情。
生化/生理作用
Prolactin (Prl) is processed to lower molecular weight N-terminal fragments, 14-18kDa, called vasoinhibins, which have antiangiogenic effects. In endothelial cells, the 16kDa prolactin form exerts antiproliferative and proapoptotic effects which result in cell cycle arrest, caspase and NFκB (nuclear factor) activation and regulation of Bcl-2 protein family. In sexually mature female mice, the plasma levels of prolactin remain constant throughout estrous cycle, but show a sudden increase during proestrous cycle due to increase in circulating levels of estrogens. Studies show that Prl activates T cells, B cells, natural killer (NK) cells, macrophages, neutrophils and dendritic cells and there is a significant level of hyperprolactinemia incidence in patients with autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Studies in rats show that Prl is involved in T cell homing to mammary glands during early lactation and that hypoprolactemia during lactation results in modified T cell distribution with increased T cell in circulation and reduced in mammary glands.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
- RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)化学品安全说明书
- RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)化学品安全说明书
- RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)化学品安全说明书
- RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书
- RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书
- RABWASH420X Wash Buffer (Item B)化学品安全说明书
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
法规信息
新产品
Conditional Deletion of the Prolactin Receptor to Identify Brain-Specific Actions of Prolactin
3 Biotech null
John D Landua et al.
Journal of mammary gland biology and neoplasia, 25(2), 145-162 (2020-07-25)
Targeted disruption of the murine Hoxd10 gene (ΔHoxd10) leads to a high frequency of localized (gland-to-gland or regionally within a gland) lactation impairment in homozygous mutant mice as a single gene mutation. The effect of Hoxd10 disruption was enhanced by
A N Johnston et al.
Breast cancer research : BCR, 20(1), 42-42 (2018-05-21)
Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation and suppresses apoptosis. It is controversial
N-terminal prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.
Ferraris J
PLoS ONE null
Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats.
Mackern-Oberti JP
Reproduction (Cambridge, England) null
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