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Merck
CN

RAB0026

Sigma-Aldrich

人类BNDF脑源性营养因子ELISA试剂盒

for serum, plasma, cell culture supernatant and urine

别名:

BDNF, Brain-derived neurotrophic factor

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About This Item

UNSPSC代码:
41116158
NACRES:
NA.32

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable
capture ELISA: suitable

输入

sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.066-16 ng/mL

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... BDNF(627)

一般描述

人 BDNF ELISA(酶联免疫吸附试验)试剂盒是一种体外酶联免疫吸附试验,用于定量测定血清、血浆、细胞培养上清液和尿液中的人 BDNF。
脑源性神经营养因子(BDNF)基因定位于人类染色体 11p14.1 上。BDNF是生长因子中神经营养蛋白家族的成员,该 该基因编码前体蛋白proBDNF。成熟的BDNF(mBDNF)是通过proBDNF的翻译后切割合成的。proBDNF 和 mBDNF 在细胞信号传导中都起着至关重要的作用。

免疫原

重组人 BDNF

应用

人BDNF ELISA试剂盒已用于:
  • 测定脑源性神经营养因子(BDNF)蛋白表达
  • 测定脑片培养基和器官型脑片培养(OBSC)提取物中的BDNF水平
  • 测定血浆BDNF水平

仅供研究使用。用于诊断程序。
人 BDNF ELISA 试剂盒已用于确定骨髓间充质干细胞 (MSC) 移植对 Tourette 综合征 (TS) 大鼠纹状体中 BDNF 蛋白表达的影响。 也用于测定 GD1(高雪氏病 1 类型)患者和对照人群的血浆 BDNF 水平。

生化/生理作用

脑源性神经营养因子(BDNF)参与人类的海马功能和言语情节记忆。因此,BDNF 基因表达的变异会改变这些神经功能。BDNF在血管功能中也起着至关重要的作用,并通过特异性受体原肌球蛋白相关激酶B(TrkB)参与血管生成。它参与了阿尔茨海默′病的发病机制。ProBDNF 与 p75 神经营养因子受体相互作用,导致海马体的长期抑制。

其他说明

本产品提供样本检验报告。
请在批号对应的文本框中输入样品 一词。

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书

  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)化学品安全说明书

  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)化学品安全说明书

  • RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书

  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书

  • RABWASH420X Wash Buffer (Item B)化学品安全说明书

象形图

Corrosion

警示用语:

Warning

危险声明

预防措施声明

危险分类

Met. Corr. 1

储存分类代码

8A - Combustible corrosive hazardous materials

法规信息

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分析证书(COA)

Lot/Batch Number

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访问文档库

Iasmin Fraga et al.
Neural regeneration research, 16(12), 2479-2485 (2021-04-29)
Epigenetic changes have been shown to be associated with both aging process and aging-related diseases. There is evidence regarding the benefits of physical activity on the functionality, cognition, and quality of life of institutionalized older adults, however, the molecular mechanisms
Running-induced functional mobility improvement in the elderly males is driven by enhanced plasma BDNF levels and the modulation of global histone H4 acetylation status
Figueiredo AI, et al.
Middle East Journal of Rehabilitation and Health Studies, 4(3) (2017)
Zuzana Paduchová et al.
Nutrients, 13(4) (2021-04-04)
In the DEPOXIN project, we have found that a high ratio of omega-6/omega-3 fatty acids (FA) is associated with worsening of depressive symptoms in children and adolescents with depressive disorder (DD) and that the 12-week omega-3 FA supplementation modulates DD
Hélio José Coelho-Júnior et al.
International journal of environmental research and public health, 17(10) (2020-05-20)
The present study compared the effects of traditional resistance training (TRT) and combined power training (PT) and TRT (PTRT) on cognitive parameters and serum brain-derived neurotrophic factor (BDNF) levels in non-demented, well-functioning, community-dwelling older women. Forty-five older women were randomized
Alexandre Silva de Mello et al.
Clinical biochemistry, 50(4-5), 228-233 (2016-11-21)
Gaucher's disease type 1 (GD1) pathophysiology includes an imbalance on brain-derived neurotrophic factor (BDNF) levels and in the inflammatory system. However, the pathways involved remain poorly understood. The hypothesis of this study is that epigenetic mechanisms might be involved, at

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