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质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
desiccated
颜色
white
溶解性
H2O: >20 mg/mL
SMILES字符串
Cl[H].COC1(COc2ccccc2O1)C3=NCCN3
InChI
1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H
InChI key
IMPOOMVZVWKSAP-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
生化/生理作用
Selective α2-adrenoceptor antagonist
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Thiago Roberto Lima Romero et al.
European journal of pharmacology, 608(1-3), 23-27 (2009-02-25)
Xylazine is an alpha(2)-adrenoceptor agonist extensively used in veterinary and animal experimentation. Evidence exists that alpha(2)-adrenoceptor agonists can activate opioid receptors via endogenous opioid release. Considering this idea and the multiple alpha(2) subtypes currently known (alpha(2A), alpha(2B), alpha(2C) and alpha(2D))
R L Almeida et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(1), R185-R192 (2011-04-09)
Lipopolysaccharide (LPS), an endotoxin from the wall of Escherichia coli, produces a general behavioral inhibition and affects several aspects of fluid-electrolyte balance. LPS inhibits thirst; however, it is not clear if it also inhibits sodium appetite. The present results show
Axel Rominger et al.
Synapse (New York, N.Y.), 64(8), 654-657 (2010-03-26)
To test for alpha(2) adrenergic modulation of dopamine D(2/3) receptor availability in striatum of living mice using the high-affinity ligand [(18)F]fallypride and microPET. Groups of anesthetized mice were pretreated with saline, the alpha(2)-agonist clonidine (1 mg/kg), and the alpha(2)-antagonists RX821002
Ana C Takakura et al.
Neuroscience letters, 450(3), 225-228 (2008-12-02)
Anti-hypertensive drugs that act on central alpha(2)-adrenoceptors and imidazoline receptors usually cause dry mouth in patients. A central area important for the control of salivary secretion and also for the effects of alpha(2)-adrenoceptor activation is the lateral hypothalamus (LH). Therefore
J Galitzky et al.
British journal of pharmacology, 100(4), 862-866 (1990-08-01)
1. The binding of a new alpha 2-adrenoceptor antagonist, [3H]-RX821002 (2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline), was investigated in human platelet membranes and compared with [3H]-yohimbine binding parameters. 2. Analysis of kinetic data revealed association and dissociation time courses consistent with a simple biomolecular reaction.
商品
Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.
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