R9525
RX 821002 hydrochloride
solid, ≥98% (HPLC)
别名:
2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H14N2O3 · HCl
化学文摘社编号:
分子量:
270.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
RX 821002 hydrochloride, solid, ≥98% (HPLC)
InChI
1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H
SMILES string
Cl[H].COC1(COc2ccccc2O1)C3=NCCN3
InChI key
IMPOOMVZVWKSAP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: >20 mg/mL
Quality Level
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Biochem/physiol Actions
Selective α2-adrenoceptor antagonist
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S Gasparini et al.
Neuroscience, 164(2), 370-379 (2009-09-01)
The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present
S J Rayment et al.
British journal of pharmacology, 160(7), 1727-1740 (2010-07-24)
We have investigated the distribution of alpha-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. Saturation and competition binding with (3)H-prazosin and (3)H-RX821002 were
J Galitzky et al.
British journal of pharmacology, 100(4), 862-866 (1990-08-01)
1. The binding of a new alpha 2-adrenoceptor antagonist, [3H]-RX821002 (2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline), was investigated in human platelet membranes and compared with [3H]-yohimbine binding parameters. 2. Analysis of kinetic data revealed association and dissociation time courses consistent with a simple biomolecular reaction.
A Bai et al.
Clinical and experimental immunology, 156(2), 353-362 (2009-03-03)
Inflammatory bowel disease (IBD) is characterized by heavy production of proinflammatory cytokines such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta. Interactions of the autonomic nervous system with local immune cells play an important role in the development of IBD
Mercè Masana et al.
The international journal of neuropsychopharmacology, 14(1), 53-68 (2010-08-13)
The superior efficacy of atypical vs. classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their ability to enhance mesocortical dopamine (DA) function. Given that noradrenergic (NE) transmission contributes to cortical DA output, we
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Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.
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