R9028
瑞格列奈
≥98% (HPLC), K-ATP channel blocker, solid
别名:
(S)-(+)-2-乙氧基-4- [N- [1-（2-哌啶苯基）-3-甲基-1-丁基] 氨基羰基甲基] 苯甲酸, Novonorm, Prandin
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H36N2O4
化学文摘社编号:
分子量:
452.59
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
瑞格列奈, ≥98% (HPLC), solid
SMILES string
CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(O)=O
InChI key
FAEKWTJYAYMJKF-QHCPKHFHSA-N
InChI
1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
assay
≥98% (HPLC)
form
solid
color
white
mp
129-130.2 °C
solubility
DMSO: >20 mg/mL
originator
Novo Nordisk
storage temp.
2-8°C
Quality Level
Gene Information
human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)
正在寻找类似产品? 访问 产品对比指南
相关类别
Application
瑞格列奈已被用作乳腺癌细胞系MDA-MB-231中的ATP敏感性钾通道（KATP）抑制剂。它还被用于制备KATP复合物，用于通过冷冻电子显微镜结构分析研究其相互作用。
Biochem/physiol Actions
瑞格列奈是一种有效的短效胰岛素促分泌剂，可通过关闭胰岛β细胞质膜中的ATP敏感性钾（KATP）通道发挥作用。
瑞格列奈是一种有效的短效胰岛素促分泌剂，可通过关闭胰岛β细胞质膜中的ATP敏感性钾（KATP）通道发挥作用。 它是一类新的胰岛素促分泌素，其结构上与磺酰脲无关，专为治疗2型糖尿病而开发。
瑞格列奈（RPG）由于起效快，可预防低血糖症。RPG引起的KATP抑制使胰腺细胞去极化β，从而导致电压门控钙通道激活，触发胰岛素释放。瑞格列奈有利于钙黄绿素通过并改善间隙连接细胞间通讯（GJIC）。从结构上看，瑞格列奈结合跨膜束中的ABC转运蛋白磺脲受体1 （SUR1）。
Features and Benefits
该化合物由Novo Nordisk开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
General description
瑞格列奈属于美格替奈类，其与格列本脲的差别在于具有庞大的B位点基团，而不是 A位点基团。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Fatima Maqoud et al.
Pharmaceutics, 13(9) (2021-09-29)
Zoledronic acid (ZOL) is used as a bone-specific antiresorptive drug with antimyeloma effects. Adverse drug reactions (A.D.R.) are associated with ZOL-therapy, whose mechanics are unknown. ZOL is a nitrogen-containing molecule whose structure shows similarities with nucleotides, ligands of ATP-sensitive K+
Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM
Martin GM, et al.
eLife, 8 (2019)
Laxmikant Ramvallabh Zawar et al.
Chemical & pharmaceutical bulletin, 60(4), 482-487 (2012-04-03)
The influence of microwave technology on the in vitro dissolution rate and in vivo antihyperglycemic activity of a poorly water soluble drug, repaglinide (RG) was studied. Solid dispersions were prepared by conventional fusion method and microwave method using poloxamer 188.
Severe thrombocytopenia due to repaglinide in a patient with type 2 diabetes.
Hisayuki Katsuyama et al.
Diabetes care, 36(3), e36-e36 (2013-02-23)
Xing-Ping Dai et al.
Clinical and experimental pharmacology & physiology, 39(5), 462-468 (2012-03-15)
The present study evaluated the effects of KCNQ1 rs2237892 and rs2237895 polymorphisms on repaglinide efficacy in Chinese patients with type 2 diabetes mellitus (T2DM). In all, 367 T2DM patients and 214 controls were genotyped. Forty of the T2DM patients were
商品
Discover Bioactive Small Molecules for ADME/Tox
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持