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R6152

雷诺嗪二盐酸盐

Name: 雷诺嗪 二盐酸盐
Brand: SIGMA
Price: 10422.78 CNY
Availability: InStock

≥98% (HPLC), powder, Na⁺-current blocker

别名:

(±)-4- [2-羟基-3-（邻甲氧基苯氧基）丙基]-1-哌嗪乙酰-2′,6′-二甲苯胺二盐酸盐, N-（2,6-二甲基苯基）-4-[2-羟基-3-（2-甲氧基苯氧基）丙基]-1-哌嗪乙酰胺二盐酸盐

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1 EA

¥10,422.78

预计发货时间2025年7月23日详情

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1 EA

¥10,422.78

About This Item

经验公式（希尔记法）:

C₂₄H₃₃N₃O₄ · 2HCl

CAS号:

95635-56-6

分子量:

500.46

MDL编号:

MFCD03788770

UNSPSC代码:

12352200

PubChem化学物质编号:

24278795

NACRES:

NA.77

¥10,422.78

预计发货时间2025年7月23日详情

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此商品	SAB1401057	SAB5701683	SAB5701160
SAB5700964 Anti- CD47 antibody produced in rabbit	SAB1401057 Anti-CD47 antibody produced in mouse	SAB5701683 Anti-CD74 antibody produced in rabbit	SAB5701160 Anti- CD44 antibody produced in rabbit
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
clone monoclonal	clone polyclonal	clone monoclonal	clone monoclonal
species reactivity human, rat, mouse	species reactivity human	species reactivity human, rat, mouse	species reactivity human, mouse, rat
Gene Information human ... CD47(961)	Gene Information human ... CD47(961)	Gene Information human ... CD74(972)	Gene Information human ... CD44(960)
UniProt accession no. Q08722	UniProt accession no. Q08722	UniProt accession no. P04233	UniProt accession no. P16070
form liquid	form buffered aqueous solution	form liquid	form liquid

应用

盐酸雷诺嗪已被用作：

低尖端扭转(TdP)风险药物，以研究其对犬心血管模型QTc延长、心电图（PR和QRS）间期的影响[1]
部分脂肪酸氧化(FAO)抑制剂，以研究其对胶质母细胞瘤细胞的作用[2]
晚期钠(Na⁺)-电流抑制剂，以研究其对兔心房性心动过速的影响。[3]

生化/生理作用

pFOX（部分脂肪酸氧化）抑制剂是一类新型的抗心绞痛药物，可抑制脂肪酸β-氧化并激活丙酮酸脱氢酶，从而使心脏的能量从脂质转移到葡萄糖，氧气消耗更少，并有助于在缺血时维持心肌功能。

雷诺嗪是抗局部缺血哌嗪的衍生物[4]，可作为钠(Na⁺)-电流抑制剂。[3]它具有治疗舒张性心力衰竭和改善心肌舒张功能的潜力。[4]

特点和优势

该化合物由Gilead开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ranolazine-Mediated Attenuation of Mechanoelectric Feedback in Atrial Myocyte Monolayers.

Irene Del-Canto et al.

Frontiers in physiology, 11, 922-922 (2020-08-28)

Mechanical stretch increases Na+ inflow into myocytes, related to mechanisms including stretch-activated channels or Na+/H+ exchanger activation, involving Ca2+ increase that leads to changes in electrophysiological properties favoring arrhythmia induction. Ranolazine is an antianginal drug with confirmed beneficial effects against

Mechanisms of ranolazine pretreatment in preventing ventricular tachyarrhythmias in diabetic db/db mice with acute regional ischemia-reperfusion injury.

Chung-Chuan Chou et al.

Scientific reports, 10(1), 20032-20032 (2020-11-20)

Studies have demonstrated that diabetic (db/db) mice have increased susceptibility to myocardial ischemia-reperfusion (IR) injury and ventricular tachyarrhythmias (VA). We aimed to investigate the antiarrhythmic and molecular mechanisms of ranolazine in db/db mouse hearts with acute IR injury. Ranolazine was

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels.

Leigh D Plant et al.

Cell reports, 30(7), 2225-2236 (2020-02-23)

Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the action potential. NaV1.5

Effects of Ranolazine and its Combination with Amiodarone on Rapid Pacing-induced Reentrant Atrial Tachycardia in Rabbits.

Isaac Aidonidis et al.

The Journal of innovations in cardiac rhythm management, 12(3), 4421-4427 (2021-03-30)

Ranolazine (RAN) has previously been shown to lower the onset of cholinergic atrial fibrillation in intact animals; however, its efficacy in the setting of atrial tachycardia (AT) is unknown. The purpose of this study was to investigate the effects of

Effects of ranolazine on cardiac function in rats with heart failure.

G-T Wang et al.

European review for medical and pharmacological sciences, 23(21), 9625-9632 (2019-11-28)

To investigate the effects of ranolazine on the cardiac function and myocardial apoptosis in rats with heart failure and its possible mechanisms. Thirty Wistar rats were randomly divided into sham operation (negative control; NC), chronic heart failure (CHF), and ranolazine

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雷诺嗪二盐酸盐

≥98% (HPLC), powder, Na⁺-current blocker

选择尺寸