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主要文件

R4643

Sigma-Aldrich

9-顺式视黄酸

≥98% (HPLC)

别名:

9-顺式维甲酸, 阿利维A酸

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10 MG
¥1,831.42

¥1,831.42


预计发货时间2025年5月16日详情


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10 MG
¥1,831.42

About This Item

经验公式(希尔记法):
C20H28O2
CAS号:
分子量:
300.44
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77

¥1,831.42


预计发货时间2025年5月16日详情


获取大包装报价

生物来源

natural

质量水平

方案

≥98% (HPLC)

表单

powder

技术

HPLC: suitable

颜色

light yellow to yellow-orange

mp

189-190 °C

储存温度

−20°C

SMILES字符串

CC1=C(\C=C\C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+

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此商品
S9679S4126S2004
grade

practical grade

grade

-

grade

-

grade

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

solid

form

solid

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

useful pH range

4.3 - 6.7

useful pH range

4.0 -7.0

useful pH range

4.0 - 7.0

useful pH range

5.0-7.5 (2% in water)

应用

9-顺式视黄酸用作:
  • 类视黄醇X受体伽玛(RXRγ)的配体,诱导少突胶质前体细胞分化和髓鞘再生[1]
  • 培养基成分,研究其对甲状腺诱导肝细胞中UDP-葡萄糖醛酸转移酶(UGT)表达的影响[2]
  • 诱导淋巴管内皮细胞中淋巴管生成 [3]

生化/生理作用

9-顺式视黄酸(9cRA)是全反式视黄酸(ATRA)的异构体,两者都是从共同前体(维生素A)合成的脂质分子。[4] 9cRA是类视黄醇X受体(RXR)和视黄酸受体(RAR)的强效激动剂。 [5] 具有神经营养功能,促进神经元分化,在治疗卒中方面可能具有治疗潜力。[6]它还能调节细胞因子分泌和淋巴细胞增殖。[4]9cRA有利于多巴胺细胞存活,在神经退行性疾病(如帕金森病)中诱导神经保护作用。 [7] 还引发抗炎功能,刺激肥大细胞,抑制白介素4和白介素5的表达水平。[8]9cRA正在进行治疗难治性癌症的II期临床试验。[5]
视黄酸受体 (RAR) 和类视色素 X 受体 (RXR) 的配体,这两种受体作为转录因子调控正常和恶性细胞的生长和分化。

特点和优势

该化合物在受体分类和信号转导手册中 核受体(非甾体化合物) 页面中进行了详细介绍。欲浏览其他手册页面,请 点击这里
该化合物是基因调控研究的推荐产品。点击这里 发现更多精选基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm

包装

密封安瓿瓶

象形图

Health hazardExclamation mark

警示用语:

Danger

危险分类

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    访问文档库

    Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis
    Perrault DP, et al.
    Lymphatic Research and Biology, 17(1), 19-29 (2019)
    Anti-inflammatory effect of 9-cis retinoic acid on the human mast cell line, HMC-1
    Lee JS and Kim IS
    The Journal of Experimental Medicine, 13(2), 149-152 (2007)
    Early post-treatment with 9-cis retinoic acid reduces neurodegeneration of dopaminergic neurons in a rat model of Parkinson?s disease
    Yin LH, et al.
    BMC Neuroscience, 13(1), 120-120 (2012)
    Yanyan Zhan et al.
    Nature chemical biology, 4(9), 548-556 (2008-08-12)
    Nuclear orphan receptor Nur77 has important roles in many biological processes. However, a physiological ligand for Nur77 has not been identified. Here, we report that the octaketide cytosporone B (Csn-B) is a naturally occurring agonist for Nur77. Csn-B specifically binds
    9-cis retinoic acid induces neurorepair in stroke brain
    Yu SJ, et al.
    Scientific reports, 7(1), 4512-4512 (2017)

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