R4033
迷迭香酸
≥98% (HPLC), from Rosemarinus officinalis L.
别名:
(R)-O-(3,4-二羟基肉桂酰)-3-(3,4-二羟苯基)乳酸, 3,4-二羟基肉桂酸 ( R )-1-羧基-2-（3,4-二羟基苯基）乙酯
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关于此项目
经验公式（希尔记法）:
C18H16O8
化学文摘社编号:
分子量:
360.31
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2227587
产品名称
迷迭香酸, ≥98% (HPLC), from Rosemarinus officinalis L.
SMILES string
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
InChI key
DOUMFZQKYFQNTF-WUTVXBCWSA-N
InChI
1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
biological source
Rosemarinus officinalis L.
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to faint beige
mp
171-175 °C (lit.)
solubility
H2O: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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Application
迷迭香酸已用于：
- 观察其对人内皮细胞系 (EA.hy926) 的保护作用，以治疗糖尿病动脉粥样硬化
- 测试其在 1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP) 诱发的帕金森症(PD)模型中减轻炎症反应和激活小胶质细胞的作用
- 测试其对多巴胺能神经元的神经保护作用
- 测试其对精子活动性、活力和细胞内钙离子浓度的影响
- 作为毛细管区带电泳 (CZE) 方法的参考标准品
Biochem/physiol Actions
迷迭香酸 (RosA) 是一种广受好评的药物，可用于治疗多种糖尿病病症和并发症，例如糖尿病肾病、糖尿病神经病变和糖尿病动脉粥样硬化。通过抑制疾病的发生条件，它还被认为是多种神经系统疾病（如阿尔茨海默症、帕金森症以及癫痫）的神经保护剂。
General description
迷迭香酸是一种天然存在于紫草科家族和荆芥科亚科植物中的多酚化合物。它是咖啡酸和3,4-二羟基-苯基乳酸的酯基。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A Oğuz et al.
Folia morphologica, 79(2), 288-295 (2019-08-23)
The aim of the study was to investigate the protective effects of rosmarinic acid in rats exposed to hepatic ischaemia/reperfusion (I/R) injury. Thirty-two rats were randomly classified into four groups of 8 rats each: laparotomy without medication, rosmarinic acid (dose
Polyphenols analysis from different medicinal plants extracts using capillary zone electrophoresis (CZE)
Matei AO, et al.,
Revista de Chimie, 67, 1051-1105 (2016)
Meng-Ge Lv et al.
Reproductive toxicology (Elmsford, N.Y.), 81, 58-63 (2018-07-17)
Rosmarinic acid (RA), a natural phenolic ester, is cytoprotective for male reproduction in animal models. The present study investigated the in vitro actions of RA on human sperm functions. Human sperm were exposed to 1, 10, 100, and 1000 μM
Tomoki Hase et al.
Scientific reports, 9(1), 8711-8711 (2019-06-20)
A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer's disease model) using DNA microarray analysis and revealed that the dopamine (DA)-signaling pathway
Robert Domitrović et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 370-378 (2012-11-03)
The aim of this study was to investigate the therapeutic potential of rosmarinic acid (RA), a natural phenolic, in the treatment of acute liver toxicity. RA at 10, 25 and 50mg/kg was administered by gavage once daily for 2 consecutive
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