R3277
吴茱萸次碱
>98% (HPLC)
别名:
8,13-二氢吲哚[2′,3′3,4]吡啶并[2,1-b] 喹唑啉-5 (7H)-酮, 吴茱萸次碱, 松树树脂
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关于此项目
经验公式（希尔记法）:
C18H13N3O
化学文摘社编号:
分子量:
287.32
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
ACVGWSKVRYFWRP-UHFFFAOYSA-N
SMILES string
O=C1N2CCc3c([nH]c4ccccc34)C2=Nc5ccccc15
InChI
1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
assay
>98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble 18 mg/mL (clear yellow solution), H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... CYP1A1(1543), CYP1A2(1544), CYP1B1(1545)
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Biochem/physiol Actions
延迟整流 K + 通道阻滞剂。抑制血小板聚集；输精管扩张器。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Máté Bubenyák
Acta pharmaceutica Hungarica, 81(4), 139-149 (2012-02-15)
Quinazolinocarboline rutaecarpine and evodiamine (Evodia rutaecarpa) are main alkaloid components of traditional Chinese folk-remedies. Evodiamine exhibited selective antitumor and antimetastatic effects on several cancer cell lines and became lead structure of anticancer agents. During our synthetic research we achieved to
Chuan-Qin Hu et al.
Journal of Asian natural products research, 14(7), 634-639 (2012-05-16)
A new natural product, 10-hydroxyrutaecarpine (1), and a rarely new glycosidic alkaloid, rutaecarpine-10-O-rutinoside (2), along with the known compounds rutaecarpine (3), evodiamine, wuzhuyuamide-I, and dehydroevodiamine were isolated from the butanol fraction of 70% ethanol aqueous extract of the dried and
Seung Ill Kim et al.
Archives of pharmacal research, 35(5), 785-789 (2012-05-31)
A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
Yong-Tai Zhang et al.
International journal of nanomedicine, 7, 2465-2472 (2012-06-09)
To investigate the cellular uptake of evodiamine and rutaecarpine in a microemulsion in comparison with aqueous suspensions and tinctures. A microemulsion was prepared using the dropwise addition method. Mouse skin fibroblasts were cultured in vitro to investigate the optimal conditions
Jian-Zhe Li et al.
Canadian journal of physiology and pharmacology, 88(10), 949-959 (2010-10-22)
Dysfunction of capsaicin-sensitive sensory nerves is involved in cardiac remodeling, and rutaecarpine has been shown to exert a beneficial effect on cardiac function through activating the sensory nerves. This study was conducted to explore the potential inhibitory effect of rutaecarpine
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