product name
视黄酸, ≥98% (HPLC), powder
生物来源
synthetic (organic)
质量水平
检测方案
≥98% (HPLC)
形式
powder
技术
cell culture | mammalian: suitable
颜色
yellow
mp
180-181 °C (lit.)
溶解性
chloroform: 50 mg/mL
储存温度
−20°C
SMILES字符串
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
基因信息
human ... RARA(5914) , RARB(5915) , RARG(5916) , RXRA(6256) , RXRB(6257) , RXRG(6258)
mouse ... Rara(19401) , Rarb(218772) , Rarg(19411) , Rxrb(20182)
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一般描述
此外，视黄酸等类视黄醇可抑制人黑素瘤细胞的增殖并刺激酪氨酸酶活性，还抑制黑色素细胞的细胞基底黏附和迁移。ATRA在哺乳动物血管系统形成中起重要作用，尤其是可以调节组织血管生成过程中的内皮细胞增殖和血管重塑。
应用
- 视黄酸（RA）已用于胚胎干细胞至运动神经元的分化。
- 它已用于非洲爪蟾外胚层至胰腺的分化。
- 它还用于研究由RARα (视黄酸受体α)引起的表观遗传学调控。
- 它已用于研究原初精原细胞向精母细胞转化的RA信号转导。
生化/生理作用
特点和优势
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
What are the I.U. for Product R2625, Retinoic acid?
This product is not characterized by the activity in I.U. The purity specification, however, is not less than 98% by HPLC.
How should I store the solutions of Product R2625, Retinoic acid?
Retinoic acid is sensitive to air and light. Solutions should be stored under argon gas, preferably as aliquots at -70°C.
What is the shelf life of Product R2625, Retinoic acid?
R2625 has a shelf-life of two years. Shelf-life dates are found on Specification sheet on our website.
Why is Product R2625, Retinoic acid not shipped on dry ice?
Dry ice is not necessary for shipment, since Product No. R2625 is stable to ship at ambient temperature for up to two weeks. Once received, it should be stored at -20°C.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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