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安全信息

R2146

Sigma-Aldrich

根赤壳霉素 来源于Diheterospora chlamydosporia

greener alternative

solid

别名:

[1aS-(1aR*,2Z,4E,14*,15aR*)]-8-氯-1a,14,15,15a-四氢-9,11-二羟基-14-甲基-6H-环氧乙烯并[e][2]苯并氧杂环-6,12(7H)-二酮, 根赤壳菌素

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About This Item

经验公式（希尔记法）:
C18H17ClO6
CAS号:
12772-57-5
分子量:
364.78
MDL编号:
MFCD06795865
UNSPSC代码:
51111800
PubChem化学物质编号:
24899351
NACRES:
NA.77

表单

solid

质量水平

200

环保替代产品得分

old score: 15
new score: 9
Find out more about DOZN™ Scoring

环保替代产品特性

Waste Prevention
Atom Economy
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

颜色

white to yellow-white

溶解性

ethanol: 10 mg/mL

抗生素抗菌谱

fungi

环保替代产品分类

, Re-engineered

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES字符串

C[C@@H]1C[C@H]2O[C@@H]2C=C\C=C\C(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1

InChI

1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1

InChI key

WYZWZEOGROVVHK-GTMNPGAYSA-N

基因信息

human ... HSP90AA1(3320) , SRC(6714)
rat ... Src(83805)

应用

根赤壳菌素（来源于Diheterospora chlamydosporia）作为热休克蛋白90(Hsp90)抑制剂已用于：
  • 研究其对秀丽隐杆线虫寿命延长和健康的影响
  • 研究其对酵母蛋白聚集的影响
  • 研究其对氧杂蒽酮敏化癌细胞的影响

生化/生理作用

根赤壳菌素是一种抗真菌大环内酯抗生素，存在于Diheterospora chlamydosporia、Chaetomium chiversii和Monosporium bonorden真菌中。它可用作酪氨酸激酶和热休克蛋白90(Hsp90)的抑制剂。根赤壳菌素参与抑制Ras、Mos和Src等各种原癌基因转化。它还可抑制丝裂原诱导型一氧化氮合酶(COX-2)和磷脂酰肌醇依赖性蛋白激酶1(PDK1)的活性。根赤壳菌素参与将细胞周期阻滞在G1-S期。它在体内具有抗癌和抗血管生成活性。

注意

光敏性

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301,H340,H350

危险分类

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000320580
0000306296
0000320580
0000306296
0000216687

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