重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
比活
49-67 nmol/min·mg
分子量
~85 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... ROCK1(6093)
生化/生理作用
ROCK1是一种普遍表达的丝氨酸/苏氨酸激酶，是小GTPase RhoA的下游靶标。ROCK1参与多种细胞功能，包括平滑肌收缩，肌动蛋白细胞骨架组织，细胞粘附和运动以及基因表达。ROCK1有助于心脏纤维化的发育和心肌细胞中纤维化细胞因子的诱导，以响应病理刺激。ROCK1基因敲除小鼠表现出减少的血管周围和间质纤维化，这与多种细胞外基质（ECM）蛋白和纤维化细胞因子的表达减少有关。
外形
以含150 mM NaCl、0.2 5 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF和25%甘油的50 mM Tris-HCl，pH 7.5的形式提供。
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Ying-Min Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20(7), 916-925 (2006-05-06)
Ventricular myocyte hypertrophy is an important compensatory growth response to pressure overload. However, pathophysiological cardiac hypertrophy is accompanied by reactive fibrosis and remodeling. The Rho kinase family, consisting of ROCK1 and ROCK2, has been implicated in cardiac hypertrophy and ventricular
Zhiyong Zhao et al.
Developmental biology, 275(1), 183-191 (2004-10-07)
Development of the endocardial cushions in the heart involves cell migration and cell differentiation, which is known as epithelial-mesenchymal transformation (EMT). These processes are regulated by cell signaling systems. Yet, the roles of intracellular GTPases and their effectors on these
Qing Zhou et al.
Hypertension (Dallas, Tex. : 1979), 69(6), 1070-1083 (2017-04-26)
Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) is an essential mediator of the pressure overload-induced cardiac hypertrophy in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2 domain containing 3), a cardiac-restricted
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