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Merck
CN
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文件

R121

Sigma-Aldrich

S(−)-雷氯必利 (+)-酒石酸盐

>97%, solid

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别名:
3,5-二氯-N-（1-乙基吡咯烷-2-基甲基）-2-羟基-6-甲氧基苯甲酰胺 (+)-酒石酸盐
经验公式（希尔记法）:
C15H20Cl2N2O3 · C4H6O6
CAS号:
98185-20-7
分子量:
497.32
MDL编号:
MFCD00274072
UNSPSC代码:
12352200
PubChem化学物质编号:
24277931
NACRES:
NA.77

质量水平

100

检测方案

>97%

形式

solid

颜色

white

溶解性

H2O: 89 mg/mL

SMILES字符串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC

InChI

1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

InChI key

QULBVRZTKPQGCR-NDAAPVSOSA-N

基因信息

human ... DRD2(1813)

相关类别

应用

S(−)-雷氯必利(+)-酒石酸盐已用作D2 受体拮抗剂：
  • 研究D2受体在介导动物PAG腹外侧区(vlPAG)/背侧中缝多巴胺能镇痛中的作用
  • Thap1缺失小鼠药理学和行为研究
  • 测定Ca2+瞬变与大鼠多巴胺神经元活性之间的关系

生化/生理作用

雷氯必利是一种苯甲酰胺衍生物和选择性D2多巴胺受体拮抗剂。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

注意

光敏性

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
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