所有图片(1)
About This Item
经验公式（希尔记法）:
C15H20Cl2N2O3 · C4H6O6
CAS号:
分子量:
497.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
>97%
表单
solid
颜色
white
溶解性
H2O: 89 mg/mL
SMILES字符串
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC
InChI
1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
InChI key
QULBVRZTKPQGCR-NDAAPVSOSA-N
基因信息
human ... DRD2(1813)
应用
S(−)-雷氯必利(+)-酒石酸盐已用作D2 受体拮抗剂：
- 研究D2受体在介导动物PAG腹外侧区(vlPAG)/背侧中缝多巴胺能镇痛中的作用
- Thap1缺失小鼠药理学和行为研究
- 测定Ca2+瞬变与大鼠多巴胺神经元活性之间的关系
生化/生理作用
雷氯必利是一种苯甲酰胺衍生物和选择性D2多巴胺受体拮抗剂。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
注意
光敏性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy
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J Kopp et al.
Neuroscience, 47(4), 771-779 (1992-01-01)
Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
H Lublin et al.
Psychopharmacology, 112(2-3), 389-397 (1993-01-01)
The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural
Vaibhav R Konanur et al.
Physiology & behavior, 215, 112771-112771 (2019-12-11)
Phasic dopamine activity is evoked by reliable predictors of food reward and plays a role in cue-triggered, goal-directed behavior. While this important signal is modulated by physiological state (e.g. hunger, satiety), the mechanisms by which physiological state is integrated by
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