R103
利坦丝林
powder
别名:
6-[2- [4-(双(4-氟苯基)亚甲基] -1-哌啶基]乙基] -7-甲基-5H-噻唑并[3,2-a]嘧啶-5-酮
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关于此项目
经验公式（希尔记法）:
C27H25F2N3OS
化学文摘社编号:
分子量:
477.57
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
color
white
solubility
methanol: >10 mg/mL, DMSO: >10.1 mg/mL, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble, dilute aqueous base: insoluble
SMILES string
CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
InChI
1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
InChI key
JUQLTPCYUFPYKE-UHFFFAOYSA-N
Gene Information
human ... HTR2A(3356)
rat ... Adra1a(29412), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr7(65032)
Application
利坦色林已用于行为测试，并用作 5-羟色胺 2A 受体（5-HT2A）受体拮抗剂。
Biochem/physiol Actions
利坦色林是有效的 5-羟色胺 2A 受体（5-HT2A）羟色胺受体拮抗剂/反向激动剂，可穿过血脑屏障。它调节 5-HT 2A 受体，并被认为具有抗帕金森作用。利坦色林还通过调节情绪、认知和消极症状来影响精神分裂症。
有效的 5-HT2A 5-羟色胺受体拮抗剂/反向激动剂，可穿越血脑屏障。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone
Hashimoto H, et al.
Journal of Neurochemistry, 110(2), 595-602 (2009)
Xiaojun Jia et al.
Neuropharmacology, 62(2), 775-783 (2011-09-20)
The key role of the hypothalamic neuropeptides orexins in maintenance and promotion of arousal has been well established in normal mammalian animals, but whether orexins exert arousal effects under pathological condition such as coma was little studied. In this study
The 5-HT 2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex
Ruiu S, et al.
Molecular Psychiatry, 5(6), 673-673 (2000)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R103-25MG | 04061836694142 |
| R103-100MG | 04061832093086 |
| R103-250MG | 04061832093093 |