Q1004
喹哌嗪 马来酸盐
serotonin/5-hydroxytryptamine-2A/C receptor agonist
别名:
2-(1-Piperazinyl)quinoline maleate salt
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关于此项目
经验公式（希尔记法）:
C13H15N3 · C4H4O4
化学文摘社编号:
分子量:
329.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
227-314-2
MDL number:
产品名称
喹哌嗪 马来酸盐,
InChI key
QYJJDHZHSCTBII-BTJKTKAUSA-N
InChI
1S/C13H15N3.C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.C1CN(CCN1)c2ccc3ccccc3n2
solubility
H2O: soluble, alcohol: soluble, dilute aqueous acid: soluble
storage temp.
2-8°C
Quality Level
Gene Information
相关类别
Application
Quipazine maleate salt has been used as a serotonin receptor agonist to study its effects on mouse models with spinal cord injury. It has also been used as a serotonin receptor agonist to study its effects on the locomotion of zebrafish.
Biochem/physiol Actions
Quipazine belongs to the class of psychedelics and acts as a serotonin/5-hydroxytryptamine-2A/C receptor agonist. It also acts as an inhibitor of prolactin.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Sabine Rehm et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 80(3), 253-257 (2007-06-16)
Observations associated with drug-induced hyper- or hypoprolactinemia in rat toxicology studies may be similar and include increased ovarian weight due to increased presence of corpora lutea. Hyperprolactinemia may be distinguished if mammary gland hyperplasia with secretion and/or vaginal mucification is
Jonathan A Norton et al.
Annals of the New York Academy of Sciences, 1198, 10-20 (2010-06-12)
Afferent inputs are known to modulate the activity of locomotor central pattern generators, but their role in the generation of locomotor patterns remains uncertain. This study sought to investigate the importance of afferent input for producing bilateral, coordinated hindlimb stepping
Elena Morelli et al.
Journal of medicinal chemistry, 52(11), 3548-3562 (2009-05-12)
The synthesis and the biological characterization of novel highly selective pyrroloquinoxaline 5-HT(3) receptor (5-HT(3)R) ligands are described. In functional and in vivo biological studies the novel quinoxalines modulated cardiac parameters by direct interaction with myocardial 5-HT(3)Rs. The potent 5-HT(3)R ligands
Chadanat Noonin
Developmental and comparative immunology, 86, 189-195 (2018-05-21)
Serotonin (5-HT) is a conserved monoamine neurotransmitter that has several physiological functions both in vertebrates and invertebrates. In addition to its well-known function in the central nervous system, 5-HT also participates in peripheral system. However, in crustaceans, the knowledge about
J M Zgombick et al.
Naunyn-Schmiedeberg's archives of pharmacology, 354(3), 226-236 (1996-08-01)
Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic compounds to inhibit forskolin-stimulated cAMP accumulation
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