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安全信息

PZ0203

Sigma-Aldrich

Sitaxentan sodium salt

≥98% (HPLC)

别名:

N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide sodium salt, Sitaxsentan sodium salt, TBC-11251 sodium salt, Thelin

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1 L
¥416.38
1 L
¥437.21
4 L
¥1,623.93
10 L
¥2,361.41

¥416.38

预计发货时间2025年4月27日详情

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变更视图
1 L
¥416.38
1 L
¥437.21
4 L
¥1,623.93
10 L
¥2,361.41

About This Item

经验公式（希尔记法）:
C18H14ClN2NaO6S2
CAS号:
210421-74-2
分子量:
476.89
UNSPSC代码:
51111800
PubChem化学物质编号:
329823772
NACRES:
NA.77

¥416.38

预计发货时间2025年4月27日详情

获取大包装报价

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: 10 mg/mL (clear solution)

储存温度

room temp

SMILES字符串

[Na+].Cc1cc2OCOc2cc1CC(=O)c3sccc3S(=O)(=O)[N-]c4onc(C)c4Cl

InChI

1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1

InChI key

MDTNUYUCUYPIHE-UHFFFAOYSA-N

基因信息

human ... EDNRA(1909) , EDNRB(1910)

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reaction suitability

reaction type: Complexometric reactions

reaction suitability

reaction type: Complexometric reactions

reaction suitability

reaction type: Complexometric reactions

reaction suitability

reaction type: Acid-base reactions, reaction type: Complexometric reactions

technique(s)

titration: suitable

technique(s)

titration: suitable

technique(s)

titration: suitable

technique(s)

titration: suitable

product line

Titripur®

product line

Titripur®

product line

Titripur®

product line

-

agency

reag. Ph. Eur.

agency

-

agency

-

agency

-

form

liquid

form

liquid

form

liquid

form

liquid

quality

Analyzed in our ISO 17025 accredited QC lab

quality

Analyzed in our ISO 17025 accredited QC lab

quality

Analyzed in our ISO 17025 accredited QC lab

quality

-

生化/生理作用

Sitaxentan (Sitaxsentan) is a potent and selective endothelin ET(A) receptor antagonist once used in the treatment of pulmonary arterial hypertension (PAH), but removed from the market because of hepatotoxicity. It is over 6000-fold selective for the the ETA receptor subtype with an IC50 of 1 nM for ETA versus an IC50 of 9800 nM for ETB.
Sitaxentan is a potent and selective endothelin ET(A) receptor antagonist; antihypertensive.
Sitaxsentan prevents shunt mediated elevation of pulmonary vascular resistance (PVR).[1] Sitaxsentan effectively inhibits basolateral Na+-taurocholate cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATPs) and bile salt export pump (BSEP).[2]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    分析证书(COA)

    Lot/Batch Number
    0000403700
    0000403700
    0000282295
    0000215850
    0000215851

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