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关于此项目
经验公式(希尔记法):
C20H13FN4O2
化学文摘社编号:
分子量:
360.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
color
faint yellow to dark orange
solubility
DMSO: >10 mg/mL, H2O: insoluble
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
[O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
InChI key
BGIYKDUASORTBB-UHFFFAOYSA-N
Gene Information
human ... MAPK14(1432)
General description
PD 169316是一种吡啶基咪唑化合物。它是p38丝裂原活化蛋白激酶的一种潜在抑制剂。它也对转化生长因子β(TGFβ)的信号转导进行抑制,特别是在人卵巢癌细胞中。
Application
PD 169316已被用于抑制人肝细胞中的p38酶。它已被用于在培养基中促进胚状体的分化。
Biochem/physiol Actions
有效的细胞通透型选择性p38激酶抑制剂(IC50 = 89 nM)。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。
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Explore all of our products under PD 169316
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells
Fu Y, et al.
Biochemical and Biophysical Research Communications, 310(2), 391-397 (2003)
Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons
Nath R, et al.
Cellular & Molecular Biology Letters, 6(2), 173-184 (2001)
A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells
Hadjal Y, et al.
Cell Death & Disease, 4(7), e737-e737 (2013)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P9248-25MG | 04061832434162 |
| P9248-5MG | 04061832434179 |

