P9178
Prochlorperazine dimaleate salt
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关于此项目
经验公式（希尔记法）:
C20H24ClN3S · 2C4H4O4
化学文摘社编号:
分子量:
606.09
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
201-511-3
MDL number:
InChI key
DSKIOWHQLUWFLG-SPIKMXEPSA-N
InChI
1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES string
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1
form
powder
solubility
H2O: slightly soluble 0.3 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL
methanol: soluble
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... DRD2(1813)
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Biochem/physiol Actions
Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic
Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
S C Lummis et al.
Neuropharmacology, 36(4-5), 665-670 (1997-04-01)
The effects of a range of phenothiazines were examined on 5-hydroxytryptamine3 (5-HT3) receptors in membranes from NIE-115 neuroblastoma cells using radioligand binding. Chlorpromazine, fluphenazine, perphenazine, trifluoperazine and prochlorperazine inhibited specific binding of both the 5-HT3 receptor antagonist [3H]GR65630 and agonist
Saunders Handbook of Veterinary Drugs - E-Book, 652-652 (2010)
Psychiatric Side Effects of Prescription and Over-the-counter Medications: Recognition and Management, 1946-1946 (1998)
Vitaliy E Kalashnikov et al.
Life (Basel, Switzerland), 11(11) (2021-11-28)
A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3-4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are currently unclear. Since hyperactivity of
Kevin Denis et al.
Nature microbiology, 4(6), 972-984 (2019-03-27)
Bacterial virulence factors are attractive targets for the development of therapeutics. Type IV pili, which are associated with a remarkable array of properties including motility, the interaction between bacteria and attachment to biotic and abiotic surfaces, represent particularly appealing virulence
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