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文件

P7791

Sigma-Aldrich

哌唑嗪 盐酸盐

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

别名:

1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-(2-呋喃甲酰基)哌嗪 盐酸盐, 脉宁平 盐酸盐

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About This Item

经验公式（希尔记法）:
C19H21N5O4 · HCl
CAS号:
19237-84-4
分子量:
419.86
Beilstein:
4303561
EC 号:
242-903-4
MDL编号:
MFCD00058177
UNSPSC代码:
12352200
PubChem化学物质编号:
24277793
NACRES:
NA.77

product name

哌唑嗪 盐酸盐, ≥99.0% (HPLC)

质量水平

100

检测方案

≥99.0% (HPLC)

形式

powder

溶解性

H2O: 0.5 mg/mL
methanol: 6 mg/mL
dilute aqueous acid: insoluble

SMILES字符串

Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4

InChI

1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H

InChI key

WFXFYZULCQKPIP-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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一般描述

哌唑嗪是一种α-肾上腺素能阻滞剂。它被视为一种周围血管舒张抗高血压药物。哌唑嗪是喹唑啉的衍生物。

应用

盐酸哌唑嗪已用于：
  • 阻断介导小鼠交感血管收缩的 α1 肾上腺素能受体
  • 作为 α1-肾上腺素受体阻滞剂，大鼠灌胃给药
  • 作为血管扩张剂，与胰岛素一起注入小鼠左心室，评价其对肾功能的影响

生化/生理作用

外周 α1-肾上腺素能受体拮抗剂；血管扩张剂。哌唑嗪可用于治疗慢性创伤后应激障碍（PTSD）。它通过舒张血管起降血压作用，因此可用于治疗高血压。

特点和优势

该化合物在《受体分类和信号转导手册》的α1-肾上腺素受体、α2-肾上腺素受体和褪黑激素页面上进行了描述。想要浏览手册的其他页面， 请单击此处。
这种化合物是 ADME 毒性和神经科学研究的特色产品。发现更多特色 ADME 毒性和神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

注意

吸湿；光敏感。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H336,H361fd,H373

危险分类

Repr. 2 - STOT RE 2 - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Nia C S Lewis et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(2), R147-R154 (2012-11-24)
We examined the hypothesis that α(1)-adrenergic blockade would lead to an inability to correct initial orthostatic hypotension (IOH) and cerebral hypoperfusion, leading to symptoms of presyncope. Twelve normotensive humans (aged 25 ± 1 yr; means ± SE) attempted to complete
Stal Saurav Shrestha et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 141-146 (2014-01-05)
The PET radioligand (11)C-CUMI-101 was previously suggested as a putative agonist radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor in recombinant cells expressing human 5-HT1A receptor. However, a recent study showed that CUMI-101 behaved as a potent 5-HT1A receptor
Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord
Yu S Q and Wang D H
Acta Pharmacologica Sinica, 32(6), 845-845 (2011)
Murray A Raskind et al.
The American journal of psychiatry, 170(9), 1003-1010 (2013-07-13)
The authors conducted a 15-week randomized controlled trial of the alpha-1 adrenoreceptor antagonist prazosin for combat trauma nightmares, sleep quality, global function, and overall symptoms in active-duty soldiers with posttraumatic stress disorder (PTSD) returned from combat deployments to Iraq and
Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis
Lim Y K, et al.
Kidney International, 58(3), 1033-1044 (2000)
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