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Merck
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安全信息

P7556

Sigma-Aldrich

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

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别名:
Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex
MDL编号:
MFCD00003658
UNSPSC代码:
12352209
PubChem化学物质编号:
57654558
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

产品线

BioReagent

形式

powder

浓度

≥65% (HPLC)

技术

cell culture | mammalian: suitable

溶解性

H2O: 25 mg/mL, clear to slightly hazy

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

基因信息

human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

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相关类别

一般描述

Progesterone is a steroid hormone secreted by the ovaries.

应用

Progesterone-Water Soluble has been used:
  • for in vitro maturation of oocyte complexes
  • as a σ1R antagonist to study its effect on sigma 1 receptor
  • to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro

This product is not recommended for use in binding assays.

生化/生理作用

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

包装

Package size based on progesterone content

其他说明

Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

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产品编号
说明
价格

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H351,H360FD,H362

危险分类

Carc. 2 - Lact. - Repr. 1A

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Neurosteroid Hormones Modulate the Differentiation of Adult Human Multipotent Mesenchymal Stromal Cells
Tiftikcioglu BI, et al.
Journal of stem cell research & therapy, 4(9), 2-2 (2012)
Clinical Reproductive Medicine and Surgery, 838, 17-17 (2007)
Adding hormones sequentially could be an effective approach for IVM of dog oocytes
Evecen M, et al.
Theriogenology, 75(9), 1647-1651 (2011)
Ligands exert Biased Activity to regulate Sigma 1 Receptor interactions with cationic TRPA1, TRPV1 and TRPM8 channels
Cortes ME, et al.
Frontiers in Pharmacology, 10(9), 634-634 (2019)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
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