P7208
Pertussis toxin
from Bordetella pertussis, lyophilized powder, protein endotoxin
别名:
IAP, PTX, 百日咳杆菌属, 组胺敏化因子, 胰岛活化蛋白
产品名称
百日咳毒素 来源于百日咳杆菌, lyophilized powder
SMILES string
O(C)C(=O)CCCCCCCCCCCCCCCCCCCCCCCC
InChI key
WOPKHAQDUMDJIY-UHFFFAOYSA-N
form
lyophilized powder
storage temp.
2-8°C
Quality Level
Gene Information
Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408)
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Application
由百日咳博德特氏菌释放的无活性毒素形式。
百日咳毒素（来自百日咳鲍特菌）用途：作为趋化因子(CXCR4)受体Gαi亚基的抑制剂，用于检测乳腺癌细胞系中的胞内Ca2+，用于分析参与ADP诱导的组织因子(TF)和P-选择素暴露的Gi信号传导，用于诱导大鼠模型的自身免疫血管炎
该毒素是以无活性形式由百日咳博德特氏菌释放的。当百日咳毒素B寡聚物结合到细胞膜上时，其A原聚体的S1亚基会被激活，这可能是通过谷胱甘肽和ATP的作用而实现的。 在体外激活百日咳毒素的实验方法是由Kaslow等提供的。
Biochem/physiol Actions
百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。
百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。 这可防止G蛋白异源三聚体与受体的相互作用，从而阻止其偶联和激活。 由于Gα亚基仍处于与GDP结合的非活性状态，因此它们无法使腺苷酸环化酶失活或打开K+通道。
Features and Benefits
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
General description
百日咳毒素(PT)是由1个活性亚基(A)和5个结合亚基(B5)组成的多亚基复合物毒素。百日咳毒素通过结合细胞表面糖基化分子经由内吞作用进入哺乳动物细胞。
Physical form
含氯化钠和磷酸钠缓冲盐的冻干粉
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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