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Merck
CN
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文件

P6532

Sigma-Aldrich

前列腺素E2

γ-irradiated, powder, BioXtra, suitable for cell culture

别名:

(5Z,11α,13E,15S)-11,15-二羟基-9-酮前列-5,13-二烯酸, PGE2, 地诺前列酮

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About This Item

经验公式（希尔记法）:
C20H32O5
CAS号:
363-24-6
分子量:
352.47
Beilstein:
4709356
EC 号:
206-656-6
MDL编号:
MFCD00077861
UNSPSC代码:
12352209
eCl@ss:
42020658
PubChem化学物质编号:
24898775
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

无菌性

γ-irradiated

产品线

BioXtra

形式

powder

效能

0.25-100 ng/mL

技术

cell culture | mammalian: suitable

溶解性

ethanol: 1 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O

InChI

1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1

InChI key

XEYBRNLFEZDVAW-ARSRFYASSA-N

基因信息

human ... PTGER1(5731) , PTGER2(5732) , PTGER3(5733) , PTGER4(5734) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

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应用

前列腺素E2已被用于测定其对肺泡细胞癌细胞系A549介导的胶原凝胶收缩的影响。
用于细胞培养应用，可用于研究前列腺素调节的细胞信号转导和基因调控。

生化/生理作用

生物活性最强的前列腺素。PGE2 可诱导宫颈成熟和分娩，介导缓激肽诱导的血管舒张，调节腺苷酸环化酶。 过表达环加氧酶2的肿瘤细胞具有更强的侵袭性、血管生成能力和细胞凋亡抵抗性，这可能是由于PGE2诱导的血管生成因子表达以及抗凋亡蛋白survivin的稳定化。PGE2 对免疫系统具有混合效应。它在体外抑制T细胞活化，表明它是一种免疫抑制剂。然而，在体内，它影响Th17亚群的扩增和T辅助细胞Th1亚群的分化，表明它是一种免疫激活剂。

外形

本品为粉末，分装后在-20°C下冷冻保存，避免反复冻融

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H360FD

危险分类

Acute Tox. 4 Oral - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Allogeneic mesenchymal stem cells (MSCs) were immunoprivileged early after cardiac implantation and improved heart function in preclinical and clinical studies. However, long-term preclinical studies demonstrated that allogeneic MSCs lost their immunoprivilege and were rejected in the injured myocardium, resulting in
Takayuki Nakagawa
Hearing research, 276(1-2), 27-33 (2011-02-08)
Prostaglandins are one of the major groups of chemical mediators in the mammalian body. Among prostaglandins, prostaglandin E2 (PGE2) is the most abundant prostanoid in humans and involved in regulating many different fundamental biological functions. PGE2 signaling is mediated by
G Almer et al.
Neurology, 58(8), 1277-1279 (2002-04-24)
Levels of the potent pro-inflammatory prostaglandin E(2) (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82%
Yumeng Mao et al.
Cancer research, 73(13), 3877-3887 (2013-05-02)
Tumors can suppress the host immune system by employing a variety of cellular immune modulators, such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells (MDSC). In the peripheral blood of patients with advanced stage melanoma, there is an
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