推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human, rat
技术
immunohistochemistry: suitable
western blot: suitable
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... P2RY1(5028)
rat ... P2ry1(25265)
一般描述
嘌呤能受体 P2Y1是G 蛋白偶联受体的成员。 P2Y1 基因定位于人染色体3q25.2。它存在于心脏、血管、前列腺、睾丸、卵巢和神经组织中。
免疫原
对应于大鼠或人P2Y1残基242-258的合成肽。
应用
兔内产生的抗嘌呤能受体 P2Y1抗体已用于免疫印迹（稀释度1:200）和免疫组化（稀释度1:50）。
生化/生理作用
嘌呤能受体 P2Y1 可用作细胞外 ATP 和 ADP 的受体。它对于 ADP 诱导的血小板活化、聚集和血栓形成至关重要。P2Y1还参与基于内皮细胞的核苷酸诱导松弛和钙动员。它是产生新的抗血小板化合物和抗炎策略的潜在靶标。
外形
从1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
未找到合适的产品？
试试我们的产品选型工具.
Milka Koupenova et al.
Frontiers in pharmacology, 9, 37-37 (2018-02-15)
Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic
J Simon et al.
Acta biologica Hungarica, 54(2), 191-201 (2003-10-11)
Since the first identification of P2Y receptor sequences in 1993, it has quickly become apparent that this family of the G-protein coupled receptors is very diverse. Members of this receptor family are activated extra-cellularly by a wide variety of adenosine
Shara Khan et al.
Diabetologia, 57(12), 2535-2545 (2014-09-12)
There is evidence that ATP acts as an autocrine signal in beta cells but the receptors and pathways involved are incompletely understood. Here we investigate the receptor subtype(s) and mechanism(s) mediating the effects of ATP on human beta cells. We
Anna Wilkaniec et al.
Purinergic signalling, 13(3), 347-361 (2017-05-19)
Abnormalities of alpha-synuclein (ASN), the main component of protein deposits (Lewy bodies), were observed in Parkinson's disease (PD), dementia with Lewy bodies, Alzheimer's disease, and other neurodegenerative disorders. These alterations include increase in the levels of soluble ASN oligomers in
Béatrice Hechler et al.
Purinergic signalling, 7(3), 293-303 (2011-07-28)
Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门