产品名称
抗-嘌呤能受体P2Y1 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, rat
technique(s)
immunohistochemistry: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... P2RY1(5028)
rat ... P2ry1(25265)
Biochem/physiol Actions
嘌呤能受体 P2Y1 可用作细胞外 ATP 和 ADP 的受体。它对于 ADP 诱导的血小板活化、聚集和血栓形成至关重要。P2Y1还参与基于内皮细胞的核苷酸诱导松弛和钙动员。它是产生新的抗血小板化合物和抗炎策略的潜在靶标。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
Application
兔内产生的抗嘌呤能受体 P2Y1抗体已用于免疫印迹（稀释度1:200）和免疫组化（稀释度1:50）。
General description
嘌呤能受体 P2Y1是G 蛋白偶联受体的成员。 P2Y1 基因定位于人染色体3q25.2。它存在于心脏、血管、前列腺、睾丸、卵巢和神经组织中。
Immunogen
对应于大鼠或人P2Y1残基242-258的合成肽。
Physical form
从1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
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J Simon et al.
Acta biologica Hungarica, 54(2), 191-201 (2003-10-11)
Since the first identification of P2Y receptor sequences in 1993, it has quickly become apparent that this family of the G-protein coupled receptors is very diverse. Members of this receptor family are activated extra-cellularly by a wide variety of adenosine
Shara Khan et al.
Diabetologia, 57(12), 2535-2545 (2014-09-12)
There is evidence that ATP acts as an autocrine signal in beta cells but the receptors and pathways involved are incompletely understood. Here we investigate the receptor subtype(s) and mechanism(s) mediating the effects of ATP on human beta cells. We
Milka Koupenova et al.
Frontiers in pharmacology, 9, 37-37 (2018-02-15)
Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic
Anna Wilkaniec et al.
Purinergic signalling, 13(3), 347-361 (2017-05-19)
Abnormalities of alpha-synuclein (ASN), the main component of protein deposits (Lewy bodies), were observed in Parkinson's disease (PD), dementia with Lewy bodies, Alzheimer's disease, and other neurodegenerative disorders. These alterations include increase in the levels of soluble ASN oligomers in
Béatrice Hechler et al.
Purinergic signalling, 7(3), 293-303 (2011-07-28)
Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive
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