质量水平
折射率
n20/D 1.425 (lit.)
bp
220 °C (lit.)
溶解性
H2O: slightly soluble
alcohol: soluble
密度
0.9 g/mL at 25 °C (lit.)
脂质类型
saturated FAs
SMILES字符串
CCCC(C(O)=O)CCC
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChI key
NIJJYAXOARWZEE-UHFFFAOYSA-N
基因信息
human ... ALDH5A1(7915) , CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)
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应用
2-丙基戊酸作为补充剂,用于小鼠胚胎成纤维细胞条件培养基(MEF-CM),培养细胞。
生化/生理作用
2-丙基戊酸是短链脂肪酸,或能抑制组蛋白去乙酰化酶的作用。可促进肿瘤细胞毒性,增加对辐射的敏感性。2-丙基戊酸可提高大脑中 γ-氨基丁酸水平。 存在过量2-丙基戊酸,则可观察到中枢神经系统作用减弱。它通过阻断电压依赖性钠通道,增强 γ-氨基丁酸(GABA)的抑制作用。
抗惊厥药,同时还具有双相障碍症情绪稳定剂的功效
警示用语:
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
231.8 °F - closed cup
闪点(°C)
111 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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