跳转至内容
Merck
CN
所有图片(4)

文件

安全信息

P6126

Sigma-Aldrich

(R)-(−)-去氧肾上腺素 盐酸盐

≥99% (titration), powder, α₁-adrenoceptor agonist

别名:

(R)-(−)-1-(3-羟基苯基)-2-甲氨基乙醇 盐酸盐, (R)-(−)-3-羟基-α-(甲氨基乙基)苄醇 盐酸盐

登录查看公司和协议定价
所有图片(4)

About This Item

线性分子式:
HOC6H4CH(CH2NHCH3)OH·HCl
CAS号:
61-76-7
分子量:
203.67
Beilstein:
4158948
EC 号:
200-517-3
MDL编号:
MFCD00012605
UNSPSC代码:
12352200
PubChem化学物质编号:
57654535
NACRES:
NA.77

product name

(R)-(−)-去氧肾上腺素 盐酸盐, powder

形式

powder

质量水平

200

mp

143-145 °C (lit.)

创始人

Johnson & Johnson

SMILES字符串

OC1=CC([C@H](CNC)O)=CC=C1.Cl

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

基因信息

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

正在寻找类似产品? 访问 产品对比指南

一般描述

(R)-(-)-去氧肾上腺素盐酸盐是一种肾上腺素能药，其作为 β-受体拟交感神经药。

应用

(R)-(-)-去氧肾上腺素盐酸盐已用于：
  • 心肌细胞和成纤维细胞的制备和培养
  • 刺激心肌条以测量 slice 收缩
  • 在原代心肌细胞培养中研究 Kruppel 样因子（KLF）对体内心肌肥大的影响
  • 评估胚胎干细胞（ESC）衍生的心肌细胞的药理反应
  • 从药理学上挽救早期胚胎致死性的 GATA（类胡萝卜素转录因子）结合蛋白 3（GATA3）空胚

生化/生理作用

α1-肾上腺素受体激动剂。

特点和优势

该化合物在受体分类和信号转导手册中α-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H317

危险分类

Acute Tox. 4 Oral - Skin Sens. 1B

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is (R)-(-)-Phenylephrine hydrochloride the same as L-Phenylephrine hydrochloride?

    (R)-(-)-Phenylephrine hydrochloride is also named l-Phenylephrine hydrochloride (lower case el) or Levophenylephrine hydrochloride.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Kruppel-like factor 4 regulates pressure-induced cardiac hypertrophy
Liao X, et al.
Journal of Molecular and Cellular Cardiology, 49(2), 334-338 (2010)
A myocardial slice culture model reveals alpha-1A-adrenergic receptor signaling in the human heart
Thomas RC, et al.
JACC. Basic to translational science, 1(3), 155-167 (2016)
Effect of basic fibroblast growth factor on cardiomyocyte differentiation from mouse embryonic stem cells.
Khezri S, et al.
Saudi Medical Journal, 28(2), 181-186 (2007)
Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1
Bhavsar PK, et al.
Journal of Cardiovascular Translational Research, 3(6), 688-695 (2010)
Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3
Udager AM, et al.
Gastroenterology, 146(1), 157-165 (2014)
查看所有相关文献

商品

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Chromatograms

application for HPLC

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门