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安全信息

P3326

Sigma-Aldrich

Platelet-Derived Growth Factor-AB 人

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

PDGF-AB

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About This Item

MDL编号:
MFCD00213024
UNSPSC代码:
12352202
NACRES:
NA.77

产品名称

Platelet-Derived Growth Factor-AB 人, PDGF-AB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

生物来源

human

质量水平

200

重组

expressed in E. coli

方案

≥97% (SDS-PAGE and N-terminal analysis)

表单

lyophilized powder

效能

10-100 ng/mL ED50/EC50

质量

endotoxin tested

分子量

27-31 kDa

包装

pkg of 10 μg
pkg of 50 μg

储存条件

avoid repeated freeze/thaw cycles

技术

cell culture | mammalian: suitable

杂质

≤1 EU/μg

UniProt登记号

P04085, P01127

储存温度

−20°C

基因信息

human ... PDGFA(5154) , PDGFB(5155)

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一般描述

Platelet-Derived Growth Factor (PDGF) is a cationic polypeptide and a constituent of α-granules. PDGF is composed of chain A and B linked together by a disulphide bridge. PDGF heterodimers occurs as PDGF-AB and homodimers exists as FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD). The PDGFB gene is localized to pericytes in the brain and is mapped to human chromosome 7p22.3.

应用

Platelet-Derived Growth Factor-AB human has been used in luciferase reporter assay.

生化/生理作用

Cellular actions of platelet-derived growth factor (PDGF) include chemoattraction and activation of neutrophils, monocytes, and fibroblasts. PDGF appears to play a crucial role in the cellular response to tissue injury and is critically involved in the pathological progression of atherosclerosis.
PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair. PDGF-AB isomer is found to be associated with angiogenesis and proliferation. Loss of PDGFB gene function induces microvascular calcification due to age-dependent phenotypical changes.

其他说明

Heterodimer of the A and B chains of PDGF disulfide linked.

外形

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid.

分析说明

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000254608
0000254608
SLCL0612
SLCJ4342
SLCG7238

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Deconstructing Fahr's disease/syndrome of brain calcification in the era of new genes
Batla A, et al.
Parkinsonism & Related Disorders, 37, 1-10 (2017)
Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.
Antoniades HN, et al.
Proceedings of the National Academy of Sciences of the USA, 88.2 , 565-569 (1991)
Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element.
Hiromura M, et al.
The Journal of Biological Chemistry, 281.38, 27753-27764 (2006)
Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy.
Freyberger H, et al.
Experimental and Clinical Endocrinology & Diabetes, 108.02, 106-109 (2000)
Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
Kohannim O, et al.
Case Reports in Genetics, 2011 (2011)
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