一般描述
鬼笔环肽是由死亡之帽鬼笔鹅膏产生的鬼笔毒素。它是一种可与肌动蛋白相互作用的环状肽，最早是在鬼笔环肽中毒的大鼠中发现的。它是一种七肽，本质上是环状的，在6位色氨酸和3位半胱氨酸之间具有交联键。鬼笔环肽中的氨基酸7（γ-δ-二羟基亮氨酸）的侧链可以进行修饰，通过该修饰可以产生荧光标记的鬼笔环肽化合物。
应用
荧光鬼笔毒素可用于鉴定丝状肌动蛋白。
鬼笔环肽-四甲基罗丹明B异硫氰酸酯已被用于：-
鬼笔环肽-四甲基罗丹明B异硫氰酸酯已被用于：-
- 在免疫荧光中对丝状肌动蛋白（F-actin）进行染色
- 在免疫细胞化学和细胞化学分析过程中对细胞进行染色
- 标记肌动蛋白微丝以进行荧光显微镜检查
生化/生理作用
鬼笔环肽与聚合肌动蛋白相互作用，而不与寡聚或单体形式相互作用。这种相互作用产生高度稳定的肌动蛋白丝，能抵抗解聚和分解。在大鼠中，这种毒素可导致肝出血死亡，细胞显示出异常的肌动蛋白聚集。鬼笔环肽化合物经衍生化荧光标记后，其对肌动蛋白的亲和力没有明显的改变。这些化合物可用于研究真核细胞内肌动蛋白的结构和组织。
结合聚合F肌动蛋白的毒素，从而稳定肌动蛋白并干扰富含肌动蛋白的结构的功能。
其他说明
可能含有混合异构体
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
高风险级别生物产品--病毒，疫苗等
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