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安全信息

P1742

Sigma-Aldrich

前白蛋白 来源于人类血浆

lyophilized powder

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别名:
甲状腺素结合前白蛋白, 甲状腺素运载蛋白
CAS号:
87090-18-4
MDL编号:
MFCD00132069
UNSPSC代码:
12352202
NACRES:
NA.25

生物来源

human plasma

质量水平

200

检测方案

≥95% (SDS-PAGE)

形式

lyophilized powder

技术

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

溶解性

H2O: soluble 1 mg/mL

ε (消光系数)

13.5 at 280 nm at 1%

UniProt登记号

P02766

储存温度

−20°C

基因信息

human ... TTR(7276)

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相关类别

一般描述

人前白蛋白是18号染色体的产物。它是一种血清蛋白，主要在肝脏中合成。 它是一种四聚体蛋白，分子量为55 kDa。人前白蛋白由非共价结合的四个相同的单体（127个氨基酸残基）组成，排列成对称的四面体。

应用

人前白蛋白用于研究肺癌血清中甲状腺素运载蛋白表达的下调。
前白蛋白（来自人血浆）已用作免疫沉淀的阳性对照作为火箭免疫电泳法定量分析脑脊液的参考标准品。

生化/生理作用

人前白蛋白可在类癌瘤中观察到。
前白蛋白水平是营养不良的指示剂，而且可能受到炎症反应调节。在慢性肾衰竭患者的透析期间，它被视为蛋白质能量营养不良(PEM)的潜在标志物。低水平的前蛋白会导致心脏衰竭(HF)风险提高。

包装

包装规格基于蛋白含量

外形

含有磷酸钠和NaCl的冻干粉

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the molecular weight of Product P1742, Prealbumin from human plasma?

    The molecular weight has been reported to be 54,980 Daltons. Referece: The Plasma Proteins, 2nd edition (1975) p. 60.

  6. What is the volume from which Product P1742, Prealbumin from human plasma, is lyophilized from?

    The starting volume is lot specific. Please contact Technical Service to obtain the exact volume of your lot of interest.

  7. What is the solubility of Product P1742, Prealbumin from human plasma?

    This product is soluble in water at 1mg/mL.

  8. What is the purity of Product P1742, Prealbumin from human plasma?

    Information about purity can be found on the lot specific certificate of analysis.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Journal of neurology, 255(10), 1526-1533 (2008-09-30)
Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic
Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
K Nelson et al.
International journal of cancer, 15(5), 806-814 (1975-05-15)
Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured in vitro. The culture supernatants of spleen cells from tumor-bearing mice inhibited (blocked) specific cell-mediated cytotoxicity to the tumor borne by the spleen donor.
Takashi Ito et al.
Internal medicine (Tokyo, Japan), 45(20), 1173-1175 (2006-11-16)
Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a
K Tashima et al.
Journal of the neurological sciences, 171(1), 19-23 (1999-11-24)
Since 1990, liver transplantation for familial amyloidotic polyneuropathy (FAP) has been carried out world-wide, and the outcome of the procedure seems to be promising. FAP is inherited systemic disease caused by mutated transthyretin. The most common cause is the valine
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