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表单
solid
质量水平
旋光性
[α]23/D −4.38°, c = 1% in methanol(lit.)
颜色
white
溶解性
0.1 M NaOH: 0.2 mg/mL
methanol: 18 mg/mL
0.1 M HCl: 20 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.4 mg/mL
H2O: insoluble
创始人
Novartis
SMILES字符串
CC(C)NC[C@H](O)COc1cccc2[nH]ccc12
InChI
1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3/t11-/m0/s1
InChI key
JZQKKSLKJUAGIC-NSHDSACASA-N
基因信息
human ... ADRB1(153) , HTR1A(3350) , HTR1B(3351)
生化/生理作用
β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Active enantiomer of pindolol.
特点和优势
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
J Ichikawa et al.
Brain research, 842(2), 445-451 (1999-10-20)
Serotonin (5-hydroxytryptamine, 5-HT)(1A) receptor agonism and 5-HT(2A) receptor antagonism are components in the action of some of the recently developed antipsychotic drugs, e.g., clozapine and ziprasidone. However, studies of the role of 5-HT(1A) receptor agonism in the ability of these
C A Fornal et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 229-238 (1999-09-22)
Clinical studies have shown that pindolol can enhance the effects of antidepressant drugs, presumably by acting as an antagonist at somatodendritic 5-hydroxytryptamine (5-HT)(1A) autoreceptors, which regulate the firing rate of central serotonergic neurons. The current study characterized the action of
D J Watkins et al.
Journal of the autonomic nervous system, 60(1-2), 12-16 (1996-08-27)
The nodose ganglion contains the cell bodies of afferent nerves which convey predominantly sensory information from the viscera to the central nervous system (CNS). Autoradiographic studies show binding sites for beta-adrenoceptor ligands are present on sections of the rat nodose
M J Millan et al.
Neuropharmacology, 38(6), 909-912 (1999-08-28)
(-)-Pindolol (2.5-20.0 mg/kg, s.c.) markedly increased extracellular levels of dopamine (DA) and noradrenaline (NA) in single dialysate samples of the frontal cortex (FCX) of freely-moving rats. This action was specific inasmuch as serotonin (5-HT) levels were not significantly modified. In
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Chromatograms
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