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P0667

小白菊内酯

Name: 小白菊内酯
Brand: SIGMA

≥98% (HPLC), NF-κB activation inhibitor, powder

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₀O₃

化学文摘社编号:

20554-84-1

分子量:

248.32

UNSPSC Code:

12352200

PubChem Substance ID:

24278621

NACRES:

NA.77

MDL number:

MFCD00134592

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

小白菊内酯, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

mp

115-116 °C (lit.)

storage temp.

2-8°C

SMILES string

C/C(CC[C@]12[H])=C/CC[C@]3(C)[C@H](O3)[C@]1(OC(C2=C)=O)[H]

InChI

1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1

InChI key

KTEXNACQROZXEV-ZRPLFPEYSA-N

Gene Information

human ... ELA2(1991), IKBKG(8517), NFKB1(4790), NKAP(79576), NKRF(55922)

说明

Application

小白菊內酯已用于：

与vasohibin 1（血管生成抑制蛋白）结合形成晶体，以便研究微管蛋白脱酪氨酸化抑制机制
作为核因子活化B细胞(NF-κB)κ-轻链增强子的抑制剂，以及信号转导和转录活化因子(STAT)的抑制剂，研究其对CD36结合恶性疟原虫感染红细胞(IECD36)的细胞粘附的影响
作为亲脂试剂，研究其对外周血来源的CD8⁺T细胞生产白介素13和干扰素γ的影响

Biochem/physiol Actions

小白菊內酯(Parthenolide)是一种倍半萜内酯，丰富存在于小白菊叶和花中。小白菊內酯具有抗癌特性，可用于治疗侵袭性癌症。小白菊內酯也可用来治疗炎症和偏头痛。它可在信号转导和转录活化因子(STAT)抑制介导的促凋亡基因转录抑制中起作用。

抑制 NF-κB 活化的抗炎剂。

Other Notes

野甘菊 ( Tanacetum parthenium ) 和其他植物中发现的倍半萜内酯。

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pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P280 - P302 + P352

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

癌症干细胞：癌症治疗的靶标

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Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.

Shanshan Pei et al.

The Journal of biological chemistry, 288(47), 33542-33558 (2013-10-04)

The development of strategies to eradicate primary human acute myelogenous leukemia (AML) cells is a major challenge to the leukemia research field. In particular, primitive leukemia cells, often termed leukemia stem cells, are typically refractory to many forms of therapy.

Parthenolide reduces cell proliferation and prostaglandin E2 [corrected] in human endometriotic stromal cells and inhibits development of endometriosis in the murine model.

Eri Takai et al.

Fertility and sterility, 100(4), 1170-1178 (2013-07-24)

To evaluate the effects of parthenolide on human endometriotic cells and murine endometriotic lesions. Experimental study. University hospital and laboratory of animal science. Twenty women with ovarian endometrioma and 30 mice. Ectopic endometrial tissue from the endometrioma was collected. Human

Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.

P A Spagnuolo et al.

Leukemia, 27(6), 1236-1244 (2013-01-16)

Parthenolide is selectively toxic to leukemia cells; however, it also activates cell protective responses that may limit its clinical application. Therefore, we sought to identify agents that synergistically enhance parthenolide's cytotoxicity. Using a high-throughput combination drug screen, we identified the

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P0667-25MG	04061834352990
P0667-5MG	04061834353003