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Merck
CN

P0547

喷他脒 羟乙基磺酸盐

NMDA glutamate receptor antagonist, powder

别名:

1,5-双（ p -脒基苯氧基）戊烷双（2-羟乙磺酸盐）, 4,4′-二苯甲脒双

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关于此项目

线性分子式:
CH2[CH2CH2OC6H4C(=NH)NH2]2·2HOCH2CH2SO3H
化学文摘社编号:
140-64-7
分子量:
592.68
NACRES:
NA.77
PubChem Substance ID:
24277999
UNSPSC Code:
12352200
EC Number:
205-424-1
MDL number:
MFCD00079213

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产品名称

喷他脒 羟乙基磺酸盐, powder

InChI key

YBVNFKZSMZGRAD-UHFFFAOYSA-N

InChI

1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)

SMILES string

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1

form

powder

mp

188-194 °C (lit.)

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

originator

Celgene

storage temp.

−20°C

Quality Level

100

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907), NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

相关类别

Application

卡氏肺囊虫抗菌药 。
异硫氰酸喷他脒盐已用于：
  • 作为抗利什曼原虫、抗疟原虫和细胞毒性试验的阳性对照
  • 作为原型化合物，分析抑制剂对人快速延迟性整流性相关基因 (HERG) K + 通道转运的影响
  • 作为前鞭毛体中的抗利什曼原虫药物

Biochem/physiol Actions

具有神经保护作用；抑制脑内组成型一氧化氮合酶；NMDA 谷氨酸受体拮抗剂。
羟乙基喷他脒作为利什曼病的二线药物。

Features and Benefits

该化合物由 Celgene 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000274392
0000274393
0000274394
0000274391
0000274394

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