所有图片(1)
别名:
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate
经验公式（希尔记法）:
C16H14F2N3O4S · Na · xH2O
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
技术
HPLC: suitable
gas chromatography (GC): suitable
颜色
white to off-white
溶解性
H2O: ≥20 mg/mL
创始人
Novartis
储存温度
−20°C
SMILES字符串
O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
InChI
1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
InChI key
CGJRLPRCWSHOFU-UHFFFAOYSA-N
基因信息
human ... ATP4A(495) , ATP4B(496)
应用
Pantoprazole sodium hydrate has been used:
- as a standard in high-performance liquid chromatography (HPLC){58
- as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
- to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines
生化/生理作用
Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.
Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.
Pantoprazole is a gastric proton pump inhibitor.
特点和优势
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
A Fitton et al.
Drugs, 51(3), 460-482 (1996-03-01)
Pantoprazole is an irreversible proton pump inhibitor which, at the therapeutic dose of 40mg, effectively reduces gastric acid secretion. In controlled clinical trials, pantoprazole (40mg once daily) has proved superior to ranitidine (300mg once daily or 150mg twice daily) and
Analysis of ibuprofen, pantoprazole, and itopride combination therapeutic drugs in human plasma by solid phase membrane microtip extraction and high-performance liquid chromatography methods using new generation core shell C18 column
Ali I, et al.
Journal of Liquid Chromatography and Related Technologies, 39(7), 339-345 (2016)
<BIG>Rissling O</BIG>
Interaction of Mycophenolic Acid and Pantoprazole: A Pharmacokinetic Crossover Study (2017)
Pantoprazole
<BIG>Perry CM and Ibbotson T</BIG>
Drugs, 101-132 (2003)
Maryam H Shubbar et al.
European journal of pharmacology, 874, 173009-173009 (2020-02-18)
Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门