P0018
泊马度胺
≥98% (HPLC), powder, HbF inducer
别名:
1,3-二氧代-2-（2,6-二氧哌啶-3-基）-4-氨基异吲哚, 3-氨基-N-（2,6-二氧代-3-哌啶基）苯甲酰胺, 4-氨基-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮, CC-4047, IMiD 3, 泊马度胺
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5 MG
¥1,746.43
25 MG
¥6,988.28
About This Item
经验公式（希尔记法）:
C13H11N3O4
CAS号:
分子量:
273.24
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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产品名称
泊马度胺, ≥98% (HPLC)
ligand
pomalidomide
质量水平
方案
≥98% (HPLC)
表单
powder
反应适用性
reagent type: ligand
颜色
yellow
溶解性
DMSO: ≥14 mg/mL
储存温度
2-8°C
SMILES字符串
Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
1 of 4
此商品 | 930563 | SML2283 | 930571 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥95% | assay ≥98% (HPLC) | assay ≥95% |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥14 mg/mL | solubility - | solubility DMSO: 2 mg/mL, clear | solubility - |
| color yellow | color - | color white to beige | color - |
应用
生化/生理作用
泊马度胺是一种有效的胎儿血红蛋白 (HbF) 诱导剂，可使关键的γ-珠蛋白抑制因子、SRY-box 转录因子 6 (SOX6) 和 BAF 染色质重塑复合物亚基 (BCL11A)下调。[3]
泊马度胺是第二代免疫调节剂，TNF-α抑制剂和沙利度胺类似物。
特点和优势
《受体分类和信号转导》手册的 细胞因子受体（肿瘤坏死受体家族） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
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说明
价格
警示用语：
Danger
危险声明
危险分类
Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Emma C Fink et al.
Blood, 132(14), 1535-1544 (2018-08-02)
Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therapeutic activity or toxicity in vivo. Here, we report the
Suzanne Lentzsch et al.
Cancer research, 62(8), 2300-2305 (2002-04-17)
Thalidomide has recently been shown to be useful in the treatment of multiple myeloma and may also be useful in the treatment of other hematological malignancies. We have identified a new derivative of thalidomide, S-3-[3-amino-phthalimido]-glutarimide (S-3APG) with dual activity against
Manh-Cuong Vo et al.
Frontiers in immunology, 9, 1798-1798 (2018-08-21)
We have previously shown that immunization with tumor antigen-loaded dendritic cells (DCs) and the immunomodulating drug, lenalidomide, synergistically potentiates the enhancing antitumor immunity in a myeloma mouse model. In this study, we investigated the immunogenicity of DCs combined with pomalidomide
Themistoklis M Tsarouchas et al.
Nature communications, 9(1), 4670-4670 (2018-11-09)
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined. Here we show that inhibiting inflammation
Yan-Rou Tsai et al.
International journal of molecular sciences, 19(10) (2018-10-24)
Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the brain is particularly vulnerable to oxidative stress. Induced by a redox state imbalance involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant
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