所有图片(1)
别名:
1,3-二氧代-2-（2,6-二氧哌啶-3-基）-4-氨基异吲哚, 3-氨基-N-（2,6-二氧代-3-哌啶基）苯甲酰胺, 4-氨基-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮, CC-4047, IMiD 3, 泊马度胺
经验公式（希尔记法）:
C13H11N3O4
推荐产品
ligand
pomalidomide
质量水平
检测方案
≥98% (HPLC)
形式
powder
反应适用性
reagent type: ligand
颜色
yellow
溶解性
DMSO: ≥14 mg/mL
储存温度
2-8°C
SMILES字符串
Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
InChI
1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key
UVSMNLNDYGZFPF-UHFFFAOYSA-N
基因信息
human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , RBX1(9978)
应用
泊马度胺已被用于：
- 处理BV173 细胞以研究蛋白质水解靶向嵌合体 (PROTAC) 化合物 JQ1-CRBN 在诱导特异性 I 类主要组织相容性复合体 (MHC-I) 肽中的作用
- 用于细胞凋亡研究和细胞内钙分析
- 作为胎儿血红蛋白 (HbF) 试剂用于研究 对& #946;-地中海贫血/变异血红蛋白 E (HbE) 红系祖细胞中胎儿血红蛋白表达水平与UNC0638 的累加效应
生化/生理作用
泊马度胺是一种有效的胎儿血红蛋白 (HbF) 诱导剂，可使关键的γ-珠蛋白抑制因子、SRY-box 转录因子 6 (SOX6) 和 BAF 染色质重塑复合物亚基 (BCL11A)下调。
泊马度胺是第二代免疫调节剂，TNF-α抑制剂和沙利度胺类似物。
特点和优势
《受体分类和信号转导》手册的 细胞因子受体（肿瘤坏死受体家族） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yan-Rou Tsai et al.
International journal of molecular sciences, 19(10) (2018-10-24)
Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the brain is particularly vulnerable to oxidative stress. Induced by a redox state imbalance involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant
Manh-Cuong Vo et al.
Frontiers in immunology, 9, 1798-1798 (2018-08-21)
We have previously shown that immunization with tumor antigen-loaded dendritic cells (DCs) and the immunomodulating drug, lenalidomide, synergistically potentiates the enhancing antitumor immunity in a myeloma mouse model. In this study, we investigated the immunogenicity of DCs combined with pomalidomide
Themistoklis M Tsarouchas et al.
Nature communications, 9(1), 4670-4670 (2018-11-09)
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined. Here we show that inhibiting inflammation
Emma C Fink et al.
Blood, 132(14), 1535-1544 (2018-08-02)
Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therapeutic activity or toxicity in vivo. Here, we report the
Susana Hernández-García et al.
Haematologica, 102(12), 2113-2124 (2017-09-02)
Kinesin spindle protein inhibition is known to be an effective therapeutic approach in several malignancies. Filanesib (ARRY-520), an inhibitor of this protein, has demonstrated activity in heavily pre-treated multiple myeloma patients. The aim of the work herein was to investigate
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