P0018
泊马度胺
≥98% (HPLC), powder, HbF inducer
别名:
1,3-二氧代-2-（2,6-二氧哌啶-3-基）-4-氨基异吲哚, 3-氨基-N-（2,6-二氧代-3-哌啶基）苯甲酰胺, 4-氨基-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮, CC-4047, IMiD 3, 泊马度胺
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关于此项目
经验公式（希尔记法）:
C13H11N3O4
化学文摘社编号:
分子量:
273.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
泊马度胺, ≥98% (HPLC)
ligand
pomalidomide
Quality Level
assay
≥98% (HPLC)
form
powder
reaction suitability
reagent type: ligand
color
yellow
solubility
DMSO: ≥14 mg/mL
storage temp.
2-8°C
SMILES string
Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
InChI
1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key
UVSMNLNDYGZFPF-UHFFFAOYSA-N
Gene Information
human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)
Application
泊马度胺已被用于：
- 处理BV173 细胞以研究蛋白质水解靶向嵌合体 (PROTAC) 化合物 JQ1-CRBN 在诱导特异性 I 类主要组织相容性复合体 (MHC-I) 肽中的作用
- 用于细胞凋亡研究和细胞内钙分析
- 作为胎儿血红蛋白 (HbF) 试剂用于研究 对& #946;-地中海贫血/变异血红蛋白 E (HbE) 红系祖细胞中胎儿血红蛋白表达水平与UNC0638 的累加效应
Biochem/physiol Actions
泊马度胺是一种有效的胎儿血红蛋白 (HbF) 诱导剂，可使关键的γ-珠蛋白抑制因子、SRY-box 转录因子 6 (SOX6) 和 BAF 染色质重塑复合物亚基 (BCL11A)下调。
泊马度胺是第二代免疫调节剂，TNF-α抑制剂和沙利度胺类似物。
Features and Benefits
《受体分类和信号转导》手册的 细胞因子受体（肿瘤坏死受体家族） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Manh-Cuong Vo et al.
Frontiers in immunology, 9, 1798-1798 (2018-08-21)
We have previously shown that immunization with tumor antigen-loaded dendritic cells (DCs) and the immunomodulating drug, lenalidomide, synergistically potentiates the enhancing antitumor immunity in a myeloma mouse model. In this study, we investigated the immunogenicity of DCs combined with pomalidomide
Themistoklis M Tsarouchas et al.
Nature communications, 9(1), 4670-4670 (2018-11-09)
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined. Here we show that inhibiting inflammation
Yan-Rou Tsai et al.
International journal of molecular sciences, 19(10) (2018-10-24)
Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the brain is particularly vulnerable to oxidative stress. Induced by a redox state imbalance involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P0018-5MG | 04061834261841 |
| P0018-25MG | 04061833213193 |