O9637
奥沙普秦
solid
别名:
4,5-Diphenyl-2-oxazolepropanoic acid, Daypro
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关于此项目
经验公式（希尔记法）:
C18H15NO3
化学文摘社编号:
分子量:
293.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-296-1
MDL number:
InChI
1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChI key
OFPXSFXSNFPTHF-UHFFFAOYSA-N
SMILES string
OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3
form
solid
Quality Level
Gene Information
human ... PTGIR(5739), PTGS1(5742), PTGS2(5743)
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General description
Oxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA). Oxaprozin binds to albumin. It inhibits arachidonic acid pathway. Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.
Application
Anti-inflammatory
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Shao-Fa Sun et al.
International journal of biological macromolecules, 39(4-5), 197-200 (2006-07-11)
The interaction between Oxaprozin-E and bovine serum albumin (BSA) was studied by spectroscopic methods including fluorescence and UV-vis absorption spectroscopy. The quenching mechanism of fluorescence of BSA by Oxaprozin-E was discussed to be a dynamic quenching procedure. The number of
Recent pharmacodynamic and pharmacokinetic findings on oxaprozin
Rainsford KD, et al.
Inflammopharmacology, 10(3), 185-239 (2002)
Isa M Kara et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 68(5), 1018-1024 (2010-03-09)
In this study, oxaprozin, a long-acting nonsteroidal anti-inflammatory drug, and naproxen sodium were compared in terms of their effects on edema, pain, and trismus after surgery for impacted mandibular third molars. Thirty healthy patients with bilaterally impacted mandibular third molars
Allen Brinker et al.
Drugs & aging, 21(7), 479-484 (2004-05-11)
Data on file with the US FDA, and other published studies, suggest that the selective cyclo-oxygenase (COX)-2 inhibitor NSAID rofecoxib has a greater hypertensive adverse effect than other NSAIDs, including celecoxib. In this study we describe a pharmacoepidemiologic analysis of
Bojan D J Božić et al.
Chemical & pharmaceutical bulletin, 60(7), 865-869 (2012-07-14)
A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized. The drug and complexes have been characterized by elemental and thermogravimetric (TG) analysis, Fourier transform (FT)-IR, 1H-NMR, 13C-NMR, UV-Vis
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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