O9387
Oxatomide
≥99%
别名:
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
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关于此项目
经验公式（希尔记法）:
C27H30N4O
化学文摘社编号:
分子量:
426.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
262-320-9
MDL number:
Quality Level
assay
≥99%
form
powder
color
white
solubility
DMSO: soluble, ethanol: soluble
originator
Johnson & Johnson
SMILES string
O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5
InChI
1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChI key
BAINIUMDFURPJM-UHFFFAOYSA-N
Gene Information
human ... DRD3(1814)
General description
Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.
Biochem/physiol Actions
Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Hiroyuki Mizuguchi et al.
Pharmaceutics, 12(6) (2020-06-12)
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine is a non-sedative
Mariko Domae et al.
The Journal of allergy and clinical immunology, 111(3), 567-572 (2003-03-19)
Eosinophils accumulated in sites of allergic inflammation are thought to play a crucial role in the pathogenesis of allergic disorders including asthma, allergic rhinitis, and atopic dermatitis, and tissue eosinophilia is attributable to increased eosinophil survival or decreased eosinophil apoptosis.
H Kimata
European journal of clinical investigation, 33(6), 513-517 (2003-06-11)
Playing video games causes physical and psychological stress, including increased heart rate and blood pressure and aggression-related feelings. Use of mobile phones is very popular in Japan, and frequent ringing is a common and intrusive part of Japanese life. Atopic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O9387-10MG | 04061834248842 |