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Merck
CN

O3639

Sigma-Aldrich

昂丹司琼 盐酸盐 二水合物

≥98% (HPLC), powder

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别名:
1,2,3,9-四氢-9-甲基-3-[(2-甲基-1H-咪唑-1-基)甲基] -4H-咔唑-4-酮 盐酸盐, GR 38032F
经验公式(希尔记法):
C18H19N3O · HCl · 2H2O
分子量:
365.85
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white

溶解性

H2O: >5 mg/mL

储存温度

−20°C

SMILES字符串

Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C

InChI

1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

InChI key

VRSLTNZJOUZKLX-UHFFFAOYSA-N

基因信息

human ... HTR3A(3359)

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应用

恩丹西酮盐酸盐二水合物已用作 5-HT3 拮抗剂,用于减弱 延髓吻段腹内侧部(RVM)/缩胆囊素(CCK)诱导的机械超敏反应,并用于阻断曲古抑菌素 A(TSA)对 5-HT3 蛋白的作用。

生化/生理作用

昂丹司琼,(3RS)-9-甲基-3-[(2-甲基-1H-咪唑-1-基)甲基] 1,2,3,9-四氢-4H-咔唑-4-酮盐酸盐脱水剂作为选择性 5-羟色胺 3 型(5-HT3)5-羟色胺受体拮抗剂。它被用作止吐剂,控制与化疗和放疗相关的恶心和呕吐。
5-HT3 血清素受体拮抗剂

特点和优势

该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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