跳转至内容
Merck
CN
所有图片(1)

主要文件

安全信息

N7032

Sigma-Aldrich

NFAT 抑制剂

>96% (HPLC), solid

别名:

VIVIT

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C75H118N20O22S
CAS号:
249537-73-3
分子量:
1683.93
MDL编号:
MFCD02683959
UNSPSC代码:
12352202
NACRES:
NA.26

质量水平

300

方案

>96% (HPLC)

表单

solid

储存温度

−20°C

SMILES字符串

S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](Cc5nc[nH]c5)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4nc[nH]c

InChI

1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)96)69(110)80-34-54(98)93-25-14-17-50(93)66(107)86-48(29-43-31-77-35-81-43)65(106)84-46(20-22-55(99)100)64(105)85-47(75(116)117)21-23-56(101)102/h31-32,35-42,45-52,57-61,96H,12-30,33-34,76H2,1-11H3,(H,77,81)(H,78,82)(H,79,103)(H,80,110)(H,83,104)(H,84,106)(H,85,105)(H,86,107)(H,87,108)(H,88,109)(H,89,113)(H,90,111)(H,91,112)(H,92,114)(H,99,100)(H,101,102)(H,116,117)/t39-,40-,41-,42+,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-,59-,60-,61-/m0/s1

InChI key

QPMHUXBSHGAVGD-MCDIZDEASA-N

基因信息

human ... NFATC1(4772) , NFATC2(4773)
mouse ... Nfatc1(18018) , Nfatc2(18019)

Amino Acid Sequence

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

应用

NFAT 抑制剂一直是活化 T 细胞核因子的抑制剂。
NFAT抑制剂VIVIT已被用于研究与控制抑制分子和随后出现的T细胞损伤有关的信号传导途径。

生化/生理作用

抑制 NFAT（活化 T 细胞核因子）活化和 T 细胞内源性细胞因子基因的 NFAT 依赖性表达。
抑制 T 细胞中 NFAT（活化 T 细胞核因子）活化和内源性细胞因子基因 NFAT 依赖性表达的高亲和力钙调神经磷酸酶结合肽。
活化T细胞的核因子（NFAT）参与免疫和非免疫细胞的活性和生长。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCD6676
BCBZ6815
BCBV0541
BCBG3639V
BCBR9829V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

p38 Mitogen-Activated Protein Kinase/Signal Transducer and Activator of Transcription-3 Pathway Signaling Regulates Expression of Inhibitory Molecules in T Cells Activated by HIV-1?Exposed Dendritic Cells
Karlhans Fu Che
Molecular Medicine (2012)
Carmela Gallo et al.
Cellular and molecular life sciences : CMLS, 79(7), 369-369 (2022-06-21)
The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF
Karlhans Fru Che et al.
Molecular medicine (Cambridge, Mass.), 18, 1169-1182 (2012-07-11)
Human immunodeficiency virus type 1 (HIV-1) infection enhances the expression of inhibitory molecules on T cells, leading to T-cell impairment. The signaling pathways underlying the regulation of inhibitory molecules and subsequent onset of T-cell impairment remain elusive. We showed that
Adolf E Schindler
International journal of women's health, 3, 175-184 (2011-07-28)
Endometriosis is a chronic disease primarily affecting women of childbearing age, in which endometriotic lesions form outside the uterus, typically leading to painful symptoms, fatigue, and infertility. The symptoms of endometriosis may cause significant impairment in quality of life and

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门