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N7032

NFAT 抑制剂

Name: NFAT 抑制剂
Brand: SIGMA

>96% (HPLC), solid

别名:

VIVIT

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关于此项目

经验公式（希尔记法）:

C₇₅H₁₁₈N₂₀O₂₂S

化学文摘社编号:

249537-73-3

分子量:

1683.93

UNSPSC Code:

12352202

NACRES:

NA.26

MDL number:

MFCD02683959

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属性

Quality Level

300

assay

>96% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](Cc5nc[nH]c5)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4nc[nH]c

InChI

1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)96)69(110)80-34-54(98)93-25-14-17-50(93)66(107)86-48(29-43-31-77-35-81-43)65(106)84-46(20-22-55(99)100)64(105)85-47(75(116)117)21-23-56(101)102/h31-32,35-42,45-52,57-61,96H,12-30,33-34,76H2,1-11H3,(H,77,81)(H,78,82)(H,79,103)(H,80,110)(H,83,104)(H,84,106)(H,85,105)(H,86,107)(H,87,108)(H,88,109)(H,89,113)(H,90,111)(H,91,112)(H,92,114)(H,99,100)(H,101,102)(H,116,117)/t39-,40-,41-,42+,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-,59-,60-,61-/m0/s1

InChI key

QPMHUXBSHGAVGD-MCDIZDEASA-N

Gene Information

human ... NFATC1(4772), NFATC2(4773)
mouse ... Nfatc1(18018), Nfatc2(18019)

说明

Application

NFAT 抑制剂一直是活化 T 细胞核因子的抑制剂。

NFAT抑制剂VIVIT已被用于研究与控制抑制分子和随后出现的T细胞损伤有关的信号传导途径。

Biochem/physiol Actions

抑制 NFAT（活化 T 细胞核因子）活化和 T 细胞内源性细胞因子基因的 NFAT 依赖性表达。

抑制 T 细胞中 NFAT（活化 T 细胞核因子）活化和内源性细胞因子基因 NFAT 依赖性表达的高亲和力钙调神经磷酸酶结合肽。

活化T细胞的核因子（NFAT）参与免疫和非免疫细胞的活性和生长。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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p38 Mitogen-Activated Protein Kinase/Signal Transducer and Activator of Transcription-3 Pathway Signaling Regulates Expression of Inhibitory Molecules in T Cells Activated by HIV-1?Exposed Dendritic Cells

Karlhans Fu Che

Molecular Medicine (2012)

Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement.

Carmela Gallo et al.

Cellular and molecular life sciences : CMLS, 79(7), 369-369 (2022-06-21)

The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF

p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells.

Karlhans Fru Che et al.

Molecular medicine (Cambridge, Mass.), 18, 1169-1182 (2012-07-11)

Human immunodeficiency virus type 1 (HIV-1) infection enhances the expression of inhibitory molecules on T cells, leading to T-cell impairment. The signaling pathways underlying the regulation of inhibitory molecules and subsequent onset of T-cell impairment remain elusive. We showed that

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全球贸易项目编号

货号	GTIN
N7032-1MG	04065265386418
N7032-.5MG	04061833421345