N6252
去甲哈尔满
≥98% (TLC), crystalline, monoamine oxidase inhibitor
别名:
β-咔啉, 9H-吡啶并[3,4-b]吲哚
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关于此项目
经验公式（希尔记法）:
C11H8N2
化学文摘社编号:
分子量:
168.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-959-0
MDL number:
产品名称
去甲哈尔满, crystalline
InChI key
AIFRHYZBTHREPW-UHFFFAOYSA-N
InChI
1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
SMILES string
c1ccc2c(c1)[nH]c3cnccc23
form
crystalline
color
light yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... IKBKB(3551)
rat ... Gabra2(29706)
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Biochem/physiol Actions
吲哚胺 2,3-双加氧酶 (IDO) 的抑制剂。
Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.
Application
Norharmane has been used:
- as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
- as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
- as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)
General description
Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
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实验方案
Explore mass spectrometry analysis of glycans for glycomic & glycoproteomic neutral & acidic glycan analysis. See a general mass spec glycan analysis procedure.
该聚糖质谱分析方案，被称之为干液滴法，基于原始的MALDI实验并依然是MS领域中最常用的方法。
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