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N5536

Sigma-Aldrich

Nefazodone hydrochloride

≥98% (HPLC), solid, antidepressant

别名:

2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride, BMY-13754, MJ-13754-1, Serzone

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About This Item

经验公式（希尔记法）:
C25H32ClN5O2 · HCl
CAS号:
82752-99-6
分子量:
506.47
MDL编号:
MFCD00935760
UNSPSC代码:
12352200
PubChem化学物质编号:
24724551
NACRES:
NA.77

产品名称

Nefazodone hydrochloride, ≥98% (HPLC), solid

质量水平

100

方案

≥98% (HPLC)

表单

solid

储存条件

desiccated

颜色

white

溶解性

DMSO: ≥10 mg/mL
H2O: insoluble

创始人

Bristol-Myers Squibb

SMILES字符串

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key

DYCKFEBIOUQECE-UHFFFAOYSA-N

基因信息

human ... HTR2A(3356) , HTR2C(3358) , SLC6A2(6530) , SLC6A4(6532)

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生化/生理作用

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

特点和优势

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000321806
0000321806
0000247033
0000247032
0000147261

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Rachel Manber et al.
Journal of consulting and clinical psychology, 76(3), 459-467 (2008-06-11)
The main aim of the present novel reanalysis of archival data was to compare the time to remission during 12 weeks of treatment of chronic depression following antidepressant medication (n = 218), psychotherapy (n = 216), and their combination (n
Laura A Bajor et al.
Harvard review of psychiatry, 19(5), 240-258 (2011-09-16)
This project aimed to provide an organized, sequential, and evidence-supported approach to the pharmacotherapy of posttraumatic stress disorder (PTSD), following the format of previous efforts of the Psychopharmacology Algorithm Project at the Harvard South Shore Program. A comprehensive literature review
Ahmed Elkashef et al.
Substance abuse, 29(3), 17-29 (2008-12-02)
Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for
Spilios V Argyropoulos et al.
Journal of sleep research, 18(3), 342-348 (2009-06-25)
It has been suggested that increase in delta sleep ratio (DSR), a marker for the relative distribution of slow wave activity (SWA) over night time, is associated with clinical response to antidepressant treatment. We examined this index and its relationship
Michael J Constantino et al.
Journal of consulting and clinical psychology, 80(3), 354-364 (2012-05-02)
Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain their depression. Recent findings support this theory and also show that patients' interpersonal impact messages, as
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