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Merck
CN
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文件

安全信息

N4267

Sigma-Aldrich

Neurokinin A

≥97% (HPLC)

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别名:
α-神经激肽
线性分子式:
C50H79N13O15S
CAS号:
86933-74-6
分子量:
1133.32
MDL编号:
MFCD00167560
UNSPSC代码:
51111800
PubChem化学物质编号:
24897700
NACRES:
NA.32

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

组成

Peptide content, ≥70%

UniProt登记号

P20366

储存温度

−20°C

SMILES字符串

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)Cc2cnc[nH]2)C(C)O)C(C)C)C(N)=O

InChI

1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)

InChI key

HEAUFJZALFKPBA-UHFFFAOYSA-N

基因信息

human ... TAC1(6863)

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相关类别

Amino Acid Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

一般描述

Neurokinin A is an 11 amino acid peptide. It is a member of tachykinin family, which includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1. The gene encoding neurokinin A is localized on human chromosome 7q21.3.

生化/生理作用

Neurokinin A improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, triggers glandular secretion and controls autonomic reflexes. Neurokinin A plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.

其他说明

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis
Janek V
Journal of Neuroimmune Pharmacology (2015)
Y Chang et al.
The Journal of pharmacology and experimental therapeutics, 294(1), 147-154 (2000-06-28)
Selective tachykinin agonists were used to identify cardiac and coronary responses mediated by specific tachykinin receptor subtypes in isolated, perfused guinea pig hearts. Receptor desensitization with selective agonists and blockade with selective antagonists were used to determine the role of
Delineation of a de novo 7q21.3q31.1 Deletion by
CGH-SNP Arrays in a Girl with Multiple Congenital
Anomalies Including Severe Glaucoma
L. Martinez-Jacobo
Molecular Syndromology (2013)
Floriane Pailleux et al.
Neurochemical research, 37(12), 2678-2685 (2012-08-11)
Vanilloid receptors have a central role in the processing of nociceptive stimuli. TRPV1 null mice showed significant decrease in response to heat noxious stimuli. However, thermal sensitivity is still present suggesting that the TRPV1 is not an exclusive transducer of
Michel R Corboz et al.
Experimental lung research, 38(5), 233-249 (2012-04-28)
The neuromodulatory action of the tachykinin NK(3)-receptor agonist [MePhe(7)]-neurokinin B ([MePhe(7)]-NKB) was evaluated on vagal stimulation-induced bronchoconstriction in nonsensitized nonchallenged and ovalbumin (OVA)-sensitized and -challenged guinea pig using the isolated perfused lung preparation. Lungs were placed inside a warmed (37°C)
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