所有图片(1)
别名:
5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine
经验公式（希尔记法）:
C18H20Cl4N4
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质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white
溶解性
DMSO: >20 mg/mL at 60 °C
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl
InChI
1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
InChI key
KNADXBVKFAUMCR-UHFFFAOYSA-N
基因信息
human ... CRHR1(1394)
应用
NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
生化/生理作用
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
The stress response neuropeptide CRF increases amyloid-beta production by regulating gamma-secretase activity
Park H J, et al.
The Embo Journal, 34(12), 1674-1686 (2015)
A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
McDowell E N, et al.
PLoS ONE, 7(10), e47359-e47359 (2012)
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Koutmani Y, et al.
Testing, 29(4), 932-945 (2019)
Takatoshi Kasai et al.
Cell reports, 30(1), 18-24 (2020-01-09)
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent pituitary induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, a functional hypothalamic-pituitary unit is generated using human
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