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Merck
CN
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文件

N3290

Sigma-Aldrich

NKH 477

≥98% (HPLC), powder, adenylyl cyclase activator

别名:

N,N-二甲基-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-（乙酰氧基）-3-乙烯基十二氢-10,10b-二羟基-3,4a,7,7,10a-五甲基-1-氧代-1H-萘 [2,1-b] 吡喃-6-基酯 b-丙氨酸 盐酸盐, 甲磺酸可福新 盐酸盐, 福斯可林

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About This Item

经验公式（希尔记法）:
C27H43NO8·HCl
CAS号:
138605-00-2
分子量:
546.09
MDL编号:
MFCD00236421
UNSPSC代码:
12352200
PubChem化学物质编号:
329818606
NACRES:
NA.77

product name

NKH 477, ≥98% (HPLC), powder

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 3 mg/mL, clear to slightly hazy (warmed)

储存温度

2-8°C

SMILES字符串

Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C

InChI

1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1

InChI key

VIRRLEDAYYYTOD-YHEOSNBFSA-N

生化/生理作用

NKH 477是一种有效的口服活性腺苷酸环化酶激活剂。它是毛喉素的水溶性衍生物，剂量依赖性基团可以增加cAMP并阻断钾诱导的平滑肌条收缩收缩（IC50 = 80 nM）。NKH 477导致组胺处理的豚鼠平滑肌变得松弛（IC50 = 32 nM）。

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

制备说明

可能出现澄清至轻微浑浊溶液。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 2 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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