N3014
β-烟酰胺腺嘌呤二核苷酸 水合物
suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast
别名:
β-DPN, β-NAD, DPN, NAD, 二磷酸吡啶核苷酸, 辅酶, 辅酶 1, 辅酶 A
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所有图片(5)
About This Item
经验公式（希尔记法）:
C21H27N7O14P2 · xH2O
CAS号:
分子量:
663.43 (anhydrous basis)
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
39200202
PubChem化学物质编号:
NACRES:
NA.55
生物来源
yeast
质量水平
检测方案
≥96.5% (HPLC)
≥96.5% (spectrophotometric assay)
形式
powder
分子量
Mw 663.43 g/mol
技术
cell culture | mammalian: suitable
杂质
≤3% Acetone
颜色
white to off-white
溶解性
H2O: 50 mg/mL
储存温度
−20°C
SMILES字符串
NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
InChI
1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI key
BAWFJGJZGIEFAR-NNYOXOHSSA-N
基因信息
human ... ESR1(2099) , ESR2(2100)
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应用
- Spectroelectrochemical Enzyme Sensor System for Acetaldehyde Detection in Wine.: This study explores the development of a novel sensor system using β-Nicotinamide adenine dinucleotide hydrate to detect acetaldehyde in wine, enhancing the accuracy of wine quality control (Ibáñez et al., 2022).
- Screening of Lactate Dehydrogenase Inhibitor from Bioactive Compounds in Natural Products by Electrophoretically Mediated Microanalysis.: The research utilizes β-Nicotinamide adenine dinucleotide hydrate to screen potential lactate dehydrogenase inhibitors, which could lead to new therapeutic agents for diseases such as cancer (Li et al., 2021).
- Combination of NAD(+) and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress.: This research highlights the neuroprotective effects of NAD+ and NADPH in stroke models, emphasizing the potential therapeutic applications of β-Nicotinamide adenine dinucleotide hydrate in neuroprotection (Huang et al., 2018).
生化/生理作用
电子受体
包装
根据固体质量包装。
其他说明
达到或超过 NRC 规范。
本品是普通型 NAD。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jeerus Sucharitakul et al.
The Journal of biological chemistry, 288(49), 35210-35221 (2013-10-17)
3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is an NADH-specific flavoprotein monooxygenase that catalyzes the para-hydroxylation of 3-hydroxybenzoate (3HB) to form 2,5-dihydroxybenzoate (2,5-DHB). Based on results from stopped-flow spectrophotometry, the reduced enzyme-3HB complex reacts with oxygen to form a C4a-peroxy
Christian Dölle et al.
The FEBS journal, 280(15), 3530-3541 (2013-04-27)
Mitochondrial metabolism is intimately connected to the universal coenzyme NAD. In addition to its role in redox reactions of energy transduction, NAD serves as substrate in regulatory reactions that lead to its degradation. Importantly, all types of the known NAD-consuming
Ana P Gomes et al.
Cell, 155(7), 1624-1638 (2013-12-24)
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but
Brian J North et al.
The EMBO journal, 33(13), 1438-1453 (2014-05-16)
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to
Anna Ferretta et al.
Biochimica et biophysica acta, 1842(7), 902-915 (2014-03-04)
Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but the molecular mechanisms controlling these events are not completely understood. Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) is a transcriptional coactivator known as master regulator of mitochondrial functions and oxidative metabolism.
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