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Merck
CN

N3014

β-烟酰胺腺嘌呤二核苷酸 水合物

greener alternative

suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

别名:

β-DPN, β-NAD, DPN, NAD, 二磷酸吡啶核苷酸, 辅酶, 辅酶 1, 辅酶 A

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关于此项目

经验公式（希尔记法）:
C21H27N7O14P2 · xH2O
化学文摘社编号:
53-84-9
分子量:
663.43 (anhydrous basis)
UNSPSC Code:
41106305
eCl@ss:
39200202
PubChem Substance ID:
24897613
NACRES:
NA.55
MDL number:
MFCD00036253
Assay:
≥96.5% (HPLC)
≥96.5% (spectrophotometric assay)
Biological source:
yeast
Form:
powder
Solubility:
H2O: 50 mg/mL
Storage temp.:
−20°C

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产品名称

β-烟酰胺腺嘌呤二核苷酸 水合物, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

SMILES string

NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

biological source

yeast

assay

≥96.5% (HPLC)
≥96.5% (spectrophotometric assay)

form

powder

mol wt

Mw 663.43 g/mol

Quality Level

200

Gene Information

human ... ESR1(2099), ESR2(2100)

greener alternative product characteristics

Waste Prevention
Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cell culture | mammalian: suitable

impurities

≤3% Acetone

color

white to off-white

solubility

H2O: 50 mg/mL

greener alternative category

DfS-Developed

storage temp.

−20°C

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相关类别

Application


  • 用于葡萄酒中乙醛检测的光谱电化学酶传感器系统。: 该研究探索了利用β-烟酰胺腺嘌呤二核苷酸水化物来检测葡萄酒中乙醛的新传感器系统的开发，增进了葡萄酒质量控制的准确率（Ibáñez et al., 2022）。

  • 通过电泳中介微分析筛查来自天然产物生物活性化合物的乳酸脱氢酶抑制剂。: 该研究利用β-烟酰胺腺嘌呤二核苷酸水化物来筛查潜在的乳酸脱氢酶抑制剂, 这些抑制剂可能引导我们开发出癌症等疾病的新治疗剂（Li et al., 2021）。

  • 在缺血性脑卒中模型中NAD(+) 和 NADPH 的组合通过释放代谢压力提供更大的神经保护作用。: 该研究重点关注NAD(+) 和 NADPH 在脑卒中模型中的神经保护作用，强调了β-烟酰胺腺嘌呤二核苷酸水化物在神经保护中的潜在治疗应用（Huang et al., 2018）。

Biochem/physiol Actions

电子受体

Other Notes

本品是普通型 NAD。
达到或超过 NRC 规范。

Packaging

根据固体质量包装。

General description

We are committed to bringing you Greener Alternative Products that adhere to one or more of the 12 Principles of Green Chemistry. Beta-Nicotinamide adenine dinucleotide is a bio-derived redox cofactor that works together with enzymes as part of a biocatalyst system. It can be efficiently recycled in many reactions, enabling selective oxidations while reducing waste and supporting greener, more sustainable chemical processes. Click here for more information.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000508488
0000508488
0000464243
0000464242
0000464247

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Christian Dölle et al.
The FEBS journal, 280(15), 3530-3541 (2013-04-27)
Mitochondrial metabolism is intimately connected to the universal coenzyme NAD. In addition to its role in redox reactions of energy transduction, NAD serves as substrate in regulatory reactions that lead to its degradation. Importantly, all types of the known NAD-consuming
Jeerus Sucharitakul et al.
The Journal of biological chemistry, 288(49), 35210-35221 (2013-10-17)
3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is an NADH-specific flavoprotein monooxygenase that catalyzes the para-hydroxylation of 3-hydroxybenzoate (3HB) to form 2,5-dihydroxybenzoate (2,5-DHB). Based on results from stopped-flow spectrophotometry, the reduced enzyme-3HB complex reacts with oxygen to form a C4a-peroxy
Ana P Gomes et al.
Cell, 155(7), 1624-1638 (2013-12-24)
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but
Brian J North et al.
The EMBO journal, 33(13), 1438-1453 (2014-05-16)
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to
Chandramohan Wakade et al.
PloS one, 9(10), e109818-e109818 (2014-10-21)
Anecdotal animal and human studies have implicated the symptomatic and neuroprotective roles of niacin in Parkinson's disease (PD). Niacin has a high affinity for GPR109A, an anti-inflammatory receptor. Niacin is also thought to be involved in the regulation of circadian
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