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Merck
CN

N3014

β-烟酰胺腺嘌呤二核苷酸 水合物

suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

别名:

β-DPN, β-NAD, DPN, NAD, 二磷酸吡啶核苷酸, 辅酶, 辅酶 1, 辅酶 A

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关于此项目

经验公式（希尔记法）:
C21H27N7O14P2 · xH2O
化学文摘社编号:
53-84-9
分子量:
663.43 (anhydrous basis)
MDL编号:
MFCD00036253
UNSPSC代码:
41106305
eCl@ss:
39200202
PubChem化学物质编号:
24897613
NACRES:
NA.55

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生物来源

yeast

质量水平

200

方案

≥96.5% (HPLC)
≥96.5% (spectrophotometric assay)

表单

powder

分子量

Mw 663.43 g/mol

技术

cell culture | mammalian: suitable

杂质

≤3% Acetone

颜色

white to off-white

溶解性

H2O: 50 mg/mL

储存温度

−20°C

SMILES字符串

NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

基因信息

human ... ESR1(2099), ESR2(2100)

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相关类别

应用


  • 用于葡萄酒中乙醛检测的光谱电化学酶传感器系统。: 该研究探索了利用β-烟酰胺腺嘌呤二核苷酸水化物来检测葡萄酒中乙醛的新传感器系统的开发，增进了葡萄酒质量控制的准确率（Ibáñez et al., 2022）。

  • 通过电泳中介微分析筛查来自天然产物生物活性化合物的乳酸脱氢酶抑制剂。: 该研究利用β-烟酰胺腺嘌呤二核苷酸水化物来筛查潜在的乳酸脱氢酶抑制剂, 这些抑制剂可能引导我们开发出癌症等疾病的新治疗剂（Li et al., 2021）。

  • 在缺血性脑卒中模型中NAD(+) 和 NADPH 的组合通过释放代谢压力提供更大的神经保护作用。: 该研究重点关注NAD(+) 和 NADPH 在脑卒中模型中的神经保护作用，强调了β-烟酰胺腺嘌呤二核苷酸水化物在神经保护中的潜在治疗应用（Huang et al., 2018）。

生化/生理作用

电子受体

包装

根据固体质量包装。

其他说明

本品是普通型 NAD。
达到或超过 NRC 规范。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000508488
0000508488
0000464243
0000464242
0000464247

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Christian Dölle et al.
The FEBS journal, 280(15), 3530-3541 (2013-04-27)
Mitochondrial metabolism is intimately connected to the universal coenzyme NAD. In addition to its role in redox reactions of energy transduction, NAD serves as substrate in regulatory reactions that lead to its degradation. Importantly, all types of the known NAD-consuming
Jeerus Sucharitakul et al.
The Journal of biological chemistry, 288(49), 35210-35221 (2013-10-17)
3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is an NADH-specific flavoprotein monooxygenase that catalyzes the para-hydroxylation of 3-hydroxybenzoate (3HB) to form 2,5-dihydroxybenzoate (2,5-DHB). Based on results from stopped-flow spectrophotometry, the reduced enzyme-3HB complex reacts with oxygen to form a C4a-peroxy
Ana P Gomes et al.
Cell, 155(7), 1624-1638 (2013-12-24)
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but
Brian J North et al.
The EMBO journal, 33(13), 1438-1453 (2014-05-16)
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to
Anna Ferretta et al.
Biochimica et biophysica acta, 1842(7), 902-915 (2014-03-04)
Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but the molecular mechanisms controlling these events are not completely understood. Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) is a transcriptional coactivator known as master regulator of mitochondrial functions and oxidative metabolism.
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