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Merck
CN

N2001

新斯的明

≥98% (HPLC and titration), acetylcholinesterase inhibitor, powder

别名:

3-(N,N-二甲氨基甲酰氧基）-N,N,N,-三甲基苯胺溴化铵, 溴化新斯的明

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关于此项目

经验公式（希尔记法）:
C12H19BrN2O2
化学文摘社编号:
114-80-7
分子量:
303.20
NACRES:
NA.77
PubChem Substance ID:
24277854
UNSPSC Code:
12352200
EC Number:
204-054-8
MDL number:
MFCD00011795
Assay:
≥98% (HPLC and titration)
Form:
powder
Quality level:
100

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产品名称

新斯的明, ≥98% (HPLC and titration), powder

InChI key

LULNWZDBKTWDGK-UHFFFAOYSA-M

InChI

1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1

SMILES string

[Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

assay

≥98% (HPLC and titration)

form

powder

color

white

mp

175-177 °C (lit.)

solubility

H2O: 1 g/mL
ethanol: soluble

Quality Level

100

Gene Information

human ... ACHE(43)

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相关类别

Application

溴新斯的明已被用作乙酰胆碱酯酶（AChE）抑制剂:
  • 用于控制乙酰胆碱酯酶在史氏菊海鞘（Botryllus schlosseri）冠状器官的反应特异性。
  • 用于研究其对幽门环形平滑肌条（PCSMS）异常收缩的影响。
  • 用于研究其对袋细胞神经元去极化的影响 。

Biochem/physiol Actions

乙酰胆碱酯酶的可逆抑制剂；不能穿过血脑屏障。
溴新斯的明是一种季胺。 它通过抑制胆碱酯酶活性而参与延长并增强乙酰胆碱的毒蕈碱和烟碱作用。它在麻醉作用中用于逆转竞争性神经肌肉阻滞剂产生的神经肌肉阻滞。
类似于毒扁豆碱的乙酰胆碱酯酶的可逆抑制剂，但是不能穿过血脑屏障。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX2160
MKCT8470
MKCQ8728
MKCQ0887
MKCQ0888

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M Weinstock et al.
The Journal of pharmacology and experimental therapeutics, 218(2), 504-508 (1981-08-01)
The influence of physostigmine was studied on the effect of morphine on the cardiovascular and respiratory systems in conscious rabbits. Morphine (4 mg/kg i.v.) caused analgesia, bradycardia, hypotension and respiratory depression, as indicated by a fall in respiratory rate of
A F Khorshid et al.
Biosensors & bioelectronics, 51, 143-149 (2013-08-21)
A novel, simple, rapid, selective and sensitive method for the determination of neostigmine (Ns) ion in its bulk powder, different pharmaceutical dosage forms, and biological fluids (plasma and urine) using four modified carbon paste electrodes was developed. Sensor 1 is
Effect of aurantii fructus immaturus flavonoid on the contraction of isolated gastric smooth muscle strips in rats
Wu Z, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2016(2), 317-328 (2016)
Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine
Khorshid, A F and Issa, Y M
Biosensors And Bioelectronics, 51, 143-149 (2014)
Zhenyu Wu et al.
Evidence-based complementary and alternative medicine : eCAM, 2016, 5616905-5616905 (2016-07-19)
This study was designed to investigate the effect of Aurantii fructus immaturus flavonoid (AFIF) on the contraction of isolated gastric smooth muscle in rats and explore its underlying mechanisms. Isolated antral longitudinal smooth muscle strip (ALSMS) and pyloric circular smooth
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